Project Summary The project outlines our plans to develop a rapid, point-of-care diagnostic test for the novel SARS-CoV-2 virus that can be used in resource-limited locations. The foundation of the project is a highly selective chemiluminescent reporter probe that produces light when activated by the major viral protease SARS-CoV-2 Mpro. This approach will enable rapid testing (<30 min) of easily obtained clinical samples (i.e., saliva) using a detector that has limited power needs and that can interface with standard smart phones to provide a diagnosis.