# African American Women Treated with tPA

> **NIH NIH U54** · MOREHOUSE SCHOOL OF MEDICINE · 2021 · $208,402

## Abstract

ABSTRACT 
Here we propose a series of studies to advance health equity in stroke. This is a collaborative program 
between Morehouse School of Medicine (MSM) Emory University, Baylor College of Medicine, and the Grady 
Memorial Hospital. MSM has established an intimate relationship and bond of trust within the minority 
community thus positioning our research team to reach high risk stroke patients and underserved minorities. 
We will develop and translate advanced technological approaches to identify which patients should receive 
thrombolytic therapy, and those patients who are at highest risk of adverse effects. We will utilize novel 
biostatistics to assess tPA therapy for stroke African American women. MSM has achieved national stature 
based on its community outreach and innovative, culturally sensitive care delivery programs. Thus the 
discovery, and establishment of translational implementation of novel solutions to health disparities in high-risk 
minority communities is our focus. Accordingly, we offer two aims: 
Aim One- Perform a prospective study of tPA safety and efficacy in African American Female Patients. 
 Retrospective analysis of tPA studies show tPA to have limited benefit in African American Women. If tPA has 
 less beneficial effect, we expect to observe a higher incidence of adverse reporting in this patient population. 
 Here we perform a prospective study to determine efficacy and safety of tPA in African American patients. 
 These data will give importance to the test determined in Aim Two. 
Aim Two- Investigate transcriptome patterns in response to tPA administration as a predictor of 
 therapeutic response. African American women have a poor response to tPA. To test the utility of RNA-Seq 
 profile to predict response to tPA, blood sample will be obtained from men and women admitted to Grady 
 Memorial Hospital who have suffered stroke. Patients who are administered thrombolytic therapy (tPA) will be 
 stratified and RNA-Seq data subjected to modeling machine learning algorithms, to identify the most accurate 
 predictive model, and compared to traditional predictors of outcome.

## Key facts

- **NIH application ID:** 10163706
- **Project number:** 5U54MD007602-34
- **Recipient organization:** MOREHOUSE SCHOOL OF MEDICINE
- **Principal Investigator:** ROGER Pancoast SIMON
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $208,402
- **Award type:** 5
- **Project period:** 1997-07-07 → 2023-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10163706

## Citation

> US National Institutes of Health, RePORTER application 10163706, African American Women Treated with tPA (5U54MD007602-34). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10163706. Licensed CC0.

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