# Neurophysiology of Human Cortical Epilepsy

> **NIH NIH R01** · MASSACHUSETTS GENERAL HOSPITAL · 2021 · $613,503

## Abstract

ABSTRACT
Epilepsy remains a devastating and poorly understood illness whose therapies are inadequate for many
patients and, in large degree, unchanged for decades. The experiments proposed in this project utilize
novel microelectrode recording techniques in patients with epilepsy as well as quantitative features and
large data sets to obtain information about the neuronal dynamics underlying epilepsy at an unprecedented
level of resolution. The primary hypothesis of this project is that this high resolution, multi-scale information
can be applied to separate seizures into different classes which differ in the mechanisms which underlie
seizure initiation. More specifically, we will be examining the role and interplay of widespread networks,
different cortical layers, infraslow activity and both excitatory and inhibitory single neuronal activity as
seizures start. We expect to find substantial differences in these different features of neural action in
different kinds of seizures. This knowledge will foster the development of a more complete understanding of
seizures and how they can be better detected, predicted and ultimately controlled.

## Key facts

- **NIH application ID:** 10163920
- **Project number:** 5R01NS062092-09
- **Recipient organization:** MASSACHUSETTS GENERAL HOSPITAL
- **Principal Investigator:** SYDNEY S CASH
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $613,503
- **Award type:** 5
- **Project period:** 2010-04-01 → 2023-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10163920

## Citation

> US National Institutes of Health, RePORTER application 10163920, Neurophysiology of Human Cortical Epilepsy (5R01NS062092-09). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10163920. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*