# Cancer Center Administration

> **NIH NIH P30** · NORTHWESTERN UNIVERSITY · 2020 · $395,000

## Abstract

We propose to purify SARS-CoV-2 proteins to build a plate or filter-based array for rapid assessment of antibody responses. Proteins will be expressed in E. coli and purified as recombinant proteins. The arrays will initially be constructed manually using a vacuum blot system or ELISA plates. If arrays prove useful, a robotic system will be retooled. In addition to proteins already under study, we would expand our library to include all of the smaller open reading frames, especially proteins E and M, which are 100% conserved with SARS. The SARS-CoV-2 proteome can be covered in a 30 protein array. These arrays would then be used to ask novel questions about the development of the immune response in different patient cohorts, including cancer patients.

## Key facts

- **NIH application ID:** 10164309
- **Project number:** 3P30CA060553-25S5
- **Recipient organization:** NORTHWESTERN UNIVERSITY
- **Principal Investigator:** Aleksandar Zafirovski
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $395,000
- **Award type:** 3
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10164309

## Citation

> US National Institutes of Health, RePORTER application 10164309, Cancer Center Administration (3P30CA060553-25S5). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10164309. Licensed CC0.

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