# Mount Sinai IMPACC COVID-19 Cores

> **NIH NIH U19** · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2020 · $5,198,360

## Abstract

As part of an NIAID/DAIT initiative we have been selected to participate in a multicenter project, namely
Immunophenotyping assessment in a COVID-19 Cohort (IMPACC), aimed to collect and distribute patient
samples and to and analyze the immune responses of 2000 COVID19 patients using specific designated
cores. The main purpose of this nationwide immunophenotyping protocol in high impact COVID-19 areas is
to perform detailed immunophenotyping and analysis of the host factors that may predict or predispose to
resolution of infection versus disease progression and its consequences. The protocol has been designed to
inform disease progression dynamics and related biomarkers; and conduct detailed, longitudinal
immunophenotyping (presentation through disease progression) that includes measures of viral load to
understand the interplay between viral load and immune pathology in disease progression. There is an
emphasis on the clinical progression by including all aspects of clinical characterization that will be needed
to match immunopathogenesis with each disease stage within each patient. IMPACC builds on the cohorts
and clinical resources and technology developed by the NAIAD/DAIT funded Clinical centers for Human
Immunology (CCHI) and the Human Immunology Project Consortia (HIPC). Thus, our team has been
selected by DAIT to participate, since Dr. Fernandez-Sesma is currently the PI of one of the HIPC centers,
named DHIPC, which studies human immune responses to dengue, chikungunya and Zika virus infection
and vaccination and Dr. Adeeb Rahman is also a crucial member of the same HIPC center and will be the
Immonophenotyping core leader for this application. Additionally, other members of the team have been
selected to participate based on their expertise in clinical sample collection and processing in hospital
settings to analyze responses to respiratory viral infections, including viral sequencing and viral load
measurement. Thus, this administrative supplement to our parent HIPC grant, named Mt Sinai IMPACC is
within the scope of our parent HIPC award, since it is focused on the study of human immune responses to a
viral infection. The team gathered for this application includes Dr. Viviana Simon, leading the clinical/sample
collection core, Dr. Adeb Rahman, that will lead the immunopheotyping core, Dr. Florian Krammer, leading
the serology Core, Dr. Harm Van Bakel, leading the virus sequencing core as well as Dr. Adolfo Garcia-
Sastre as a co-investigator and Dr. Jaime Hook as a pulmonologist in the clinic. With this team and the
availability of clinical samples and the appropriate resources and biocontainment at our site we are poised to
provide samples and to analyze the different immune and viral parameters that will help us understand
disease severity and progression in during the COVID19 pandemic. Mount Sinai Hospital is located in New
York City, which is at the epicenter of this pandemic in the US and is already treating hundreds of COVID
pa...

## Key facts

- **NIH application ID:** 10164931
- **Project number:** 3U19AI118610-06S1
- **Recipient organization:** ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- **Principal Investigator:** Ana Fernandez-Sesma
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $5,198,360
- **Award type:** 3
- **Project period:** 2020-06-05 → 2023-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10164931

## Citation

> US National Institutes of Health, RePORTER application 10164931, Mount Sinai IMPACC COVID-19 Cores (3U19AI118610-06S1). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10164931. Licensed CC0.

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