# Commercialization of a CT-based Technique for BOS Assessment

> **NIH NIH R44** · IMBIO, LLC · 2021 · $459,828

## Abstract

Patients who have undergone allogenic hematopoietic stem cell transplantation (allo-HSCT) or lung 
transplantation often develop pulmonary complications. These transplant recipients often develop a 
potentially life threatening condition known as bronchiolitis obliterans syndrome (BOS), a 
consequence of graft versus host disease (GVHD). Early diagnosis of BOS is vital for maintaining 
quality of life and improving overall survival, as few treatment options exist once BOS becomes 
established in lung tissue. Treatments for BOS remain limited, as other pulmonary complications 
with similar symptoms to BOS, such as infections, are prevalent and ultimately delay diagnosis. 
Clinical access to the PRM technology, with its ability to simultaneously delineate specific 
diseases, would have an immediate and positive impact on this patient population. For this 
promising technology to enter routine clinical use for transplant recipients a commercial 
application must be developed, tested and integrated within the clinical workflow using relevant CT 
data and a PRM technique adapted to this patient population. In this grant effort, we propose to 
achieve this goal through our close partnership between University of Michigan (UM) and Imbio, LLC 
investigators. Thus the Specific Aims of this Fast-Track proposal will develop a commercial PRM 
software application, including product testing and data acquisition necessary for a FDA 510(k) 
application using paired CT data and HSCT and lung transplant recipient information.

## Key facts

- **NIH application ID:** 10165795
- **Project number:** 5R44HL140894-04
- **Recipient organization:** IMBIO, LLC
- **Principal Investigator:** Craig J Galban
- **Activity code:** R44 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $459,828
- **Award type:** 5
- **Project period:** 2018-08-01 → 2022-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10165795

## Citation

> US National Institutes of Health, RePORTER application 10165795, Commercialization of a CT-based Technique for BOS Assessment (5R44HL140894-04). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10165795. Licensed CC0.

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