# Discovery of agents that induce exosomes with adjuvant activity

> **NIH NIH N01** · SCRIPPS INSTITUTION OF OCEANOGRAPHY · 2020 · $2,073,158

## Abstract

The contractor will identify novel adjuvant candidates that can be used to augment the efficacy of human vaccines. Research performed under this award will contribute to the pipeline of new adjuvant leads that either: (a) exploit the natural capacity of the innate immune system to initiate and sustain effective T and B cell responses and to induce long term immune memory, or (b) act directly on cells of the adaptive immune system to enhance their response to pathogen-derived antigens.
 
Studies include testing of adjuvant candidates with experimental or FDA approved preventative or therapeutic vaccines in relevant animal models to determine the potential efficacy of the vaccine against one or more pathogens relevant to human disease.

## Key facts

- **NIH application ID:** 10166664
- **Project number:** 75N93019C00042-P00004-9999-1
- **Recipient organization:** SCRIPPS INSTITUTION OF OCEANOGRAPHY
- **Principal Investigator:** DENNIS CARSON
- **Activity code:** N01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $2,073,158
- **Award type:** —
- **Project period:** 2019-09-30 → 2024-09-29

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10166664

## Citation

> US National Institutes of Health, RePORTER application 10166664, Discovery of agents that induce exosomes with adjuvant activity (75N93019C00042-P00004-9999-1). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10166664. Licensed CC0.

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