# Imaging Management and Analysis Core

> **NIH NIH U54** · OREGON HEALTH & SCIENCE UNIVERSITY · 2021 · $204,078

## Abstract

ABSTRACT – Imaging Management and Analysis Core 
The Imaging Management and Analysis Core (Imaging Core) will meet the requirements of the three 
Measuring, Modeling, and Controlling Heterogeneity-Cancer Systems Biology Consortium (M2CH-CSBC) 
Projects and the Outreach Core by developing and integrating state-of-the-art resources for a complete 
imaging workflow. Specifically, we will 1) use high-content imaging to measure baseline and drug and 
microenvironment response phenotypes separately and in combination in a panel of cell lines, 2) optimize and 
deploy novel, highly multiparameter cyclic multiplexed immunofluorescence (cmIF) imaging workflows to 
measure microenvironment and drug responses in heterogeneous tissues in 2D and 3D, and 3) deploy 
correlative light/electron microscopic analysis based on super-resolution light microscopy and scanning 
electron microscopy to provide the ultrastructural cellular context. To execute these tasks in close collaboration 
with the Projects, the Imaging Core will expand on existing resources and build a customized imaging 
environment to a) acquire image data in automated ways from the multiple imaging instruments, following 
precise protocols and maintaining complete metadata, b) store images and metadata and all derived and 
associated measurement data in highly robust databases and repositories with powerful query, visualization, 
and programmer access tools, c) quantitatively analyze images by deploying and developing state-of-the-art 
image reconstruction methods, image segmentation algorithms, feature extraction and classification routines, 
normalization procedures, and machine learning approaches to classify image features at multiple resolution 
levels, and d) develop novel visualization methods for interacting with images and extracted features and 
models in combination with experimental metadata and data from external databases.

## Key facts

- **NIH application ID:** 10166786
- **Project number:** 5U54CA209988-05
- **Recipient organization:** OREGON HEALTH & SCIENCE UNIVERSITY
- **Principal Investigator:** JOE W. GRAY
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $204,078
- **Award type:** 5
- **Project period:** 2020-05-01 → 2023-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10166786

## Citation

> US National Institutes of Health, RePORTER application 10166786, Imaging Management and Analysis Core (5U54CA209988-05). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10166786. Licensed CC0.

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