# Wisconsin Alzheimer's Disease Research center

> **NIH NIH P30** · UNIVERSITY OF WISCONSIN-MADISON · 2020 · $387,035

## Abstract

PROJECT SUMMARY - OVERALL
The overall goal of the renewal of the Wisconsin Alzheimer's Disease Research Center (ADRC) is to support
cutting-edge, innovative research on the pathobiology, early diagnosis and treatment of Alzheimer's disease
(AD) and related illnesses. This goal will be accomplished by establishing a stimulating, interdisciplinary
environment for collaborative research and providing invaluable clinical data, ante-mortem biospecimens, and
autopsy brain tissue. Funded by NIA in 2009, the Wisconsin ADRC will support eight well-integrated Cores,
including a new Care Research Core and Research Education Component (REC) that will support timely,
innovative research, which will: 1) characterize preclinical biomarkers of AD and their role in predicting transition
from preclinical to clinical stages of the disease; 2) investigate the neurobiology of AD; 3) identify novel vascular
and genetic risk factors, linking them to the disease pathology and clinical phenotype; 4) incorporate
contemporary biochemical and molecular techniques into clinical-pathologic cohort studies, including omics and
next generation genetic sequencing; and 5) participate and facilitate the missions of other federal, state and local
agency-supported aging and dementia research programs. The overall goals of the Center will be accomplished
through coordinated activities of its eight Cores and the REC. The Administrative Core will provide scientific
leadership to the ADRC as a whole. The Clinical Core will perform standardized evaluations and collect UDS
and additional data on all research participants. It will work closely with the Outreach, Recruitment and
Engagement (ORE) Core and the Inclusion of Underrepresented Groups (URG) Core to enhance enrollment
of underrepresented minorities. The Data Management and Statistical (DMS) Core will continue to meet all
data management, informatics, and statistical needs and support all the PC- and web-based services and
processes. The Neuropathology Core will continue to provide neuropathologic diagnoses and process,
store, and distribute antemortem biospecimens and postmortem brain tissue to support novel research in AD.
The ORE Core will provide a broad-range of educational and outreach programs about AD and the
Wisconsin ADRC missions to recruit research volunteers, especially those from URGs into the Clinical Core and
other NIA-funded initiatives, such as ADCS, ADNI, NCRAD and GWAS studies. The URG Core will work closely
with the ORE and Clinical Cores to enhance recruitment and retention of URG participants into the ADRC. The
new Biomarker Core will support and provide access to resources in preclinical neuroimaging and cerebrospinal
fluid (CSF) biomarkers of AD. The REC will coordinate closely with the Clinical, ORE, URG, Neuropathology and
DMS Cores to provide state-of-the-art, competency-based training to postdoctoral fellows and early-stage faculty
in all aspects of aging & dementia research. The new Care Research Core wi...

## Key facts

- **NIH application ID:** 10167392
- **Project number:** 3P30AG062715-02S3
- **Recipient organization:** UNIVERSITY OF WISCONSIN-MADISON
- **Principal Investigator:** Sanjay Asthana
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $387,035
- **Award type:** 3
- **Project period:** 2019-05-01 → 2024-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10167392

## Citation

> US National Institutes of Health, RePORTER application 10167392, Wisconsin Alzheimer's Disease Research center (3P30AG062715-02S3). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10167392. Licensed CC0.

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