# Social modifiers of the pace of aging across multiple domains and tissues

> **NIH NIH R01** · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · 2020 · $52,635

## Abstract

The size of the elderly population in the United States is increasing rapidly. As individuals age,
their mobility is impacted through the development of degenerative joint disease (DJD),
reducing their ability to interact with both the social and physical aspects of the world, so
reducing quality of life. This supplement adds new measures of skeletal health to the parent
proposal, which tracks naturalistic molecular and immunological changes in a nonhuman
primate model across the lifespan. The specific objective of the supplement is to probe the
relationship between aging signatures in the genome across tissues, immune function and
inflammation, and the onset of age-related bone diseases, in order to assess the potential for
biomarkers of DJD that can be measured before the onset of physical symptoms. As part of this
project, a permanent digital archive will be created to preserve skeletons of rhesus macaques
who are being studied for the parent proposal, and to promote external research access to that
collection. In addition to providing a comprehensive and highly-novel dataset on the etiology of
age-related skeletal diseases in a non-human primate model, it will also be key to the career
development of a post-doctoral researcher from an underrepresented background, who will
expand on their current skillset by learning immunoassay and molecular techniques, and by
exploring new avenues of inquiry in skeletal health and aging biology.

## Key facts

- **NIH application ID:** 10167544
- **Project number:** 3R01AG060931-02S1
- **Recipient organization:** ARIZONA STATE UNIVERSITY-TEMPE CAMPUS
- **Principal Investigator:** Lauren Johanna Nicole Brent
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $52,635
- **Award type:** 3
- **Project period:** 2019-07-01 → 2024-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10167544

## Citation

> US National Institutes of Health, RePORTER application 10167544, Social modifiers of the pace of aging across multiple domains and tissues (3R01AG060931-02S1). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10167544. Licensed CC0.

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