# Racial Disparity in Bladder Cancer and Identification of Altered Metabolism in African American Compare to European Bladder Cancer

> **NIH NIH R01** · BAYLOR COLLEGE OF MEDICINE · 2021 · $361,296

## Abstract

Project Summary/Abstract
It has known that bladder cancer (BCa) mortality is higher in African American patients. Disparity exists
between African-American (AA) and European-American (EA), in the clinical outcome of BCa. The long-term
objective of our research plan is to reduce the disproportionate effects of bladder cancer (BCa) on African
American. A guiding principle of our methodology is that alterations in mitochondrial metabolites exist between
African American and European American BCa and that these differences can explain, in part, BCa health
disparity. In this application, we propose to use the technique of metabolomic profiling to uncover these
underlying differences. To date, a metabolomic analyses aimed at understanding of bladder cancer health
disparity has not been reported. We have recently published the first study describing metabolic alterations
associated with bladder cancer. In preliminary studies, we have profiled the metabolome of BCa from AA and
EA patients and identified a distinct AA race-specific expression pattern in mitochondrial metabolites and lipids.
In this proposal, we will i) characterize the mitochondrial associated metabolites in AA and EA BCa, ii) verify
the D-2HG and associated enzymes (GLS, ADHFE1, and IDH1/2) in BCa patients and establish a
therapeutically targeted deregulation pathway for glutamine metabolism in AA BCa iii) assess the levels of lyso
PC and PC and the function of their metabolizing enzymes PLA1A and LRAT in AA BCa. The successful
completion of the proposed studies will have a significant impact in the field of Bladder cancer health disparity
and metabolism. Importantly, findings from our study have the potential to reveal racially exclusive metabolic
markers and therapeutic targets for BCa. Taken together, the information gleaned from this proposal could
rapidly revolutionize current diagnostic, prognostic and therapeutic approaches by revealing the biological
underpinnings of bladder cancer health disparity.

## Key facts

- **NIH application ID:** 10167647
- **Project number:** 5R01CA220297-05
- **Recipient organization:** BAYLOR COLLEGE OF MEDICINE
- **Principal Investigator:** Nagireddy Putluri
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $361,296
- **Award type:** 5
- **Project period:** 2017-06-05 → 2023-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10167647

## Citation

> US National Institutes of Health, RePORTER application 10167647, Racial Disparity in Bladder Cancer and Identification of Altered Metabolism in African American Compare to European Bladder Cancer (5R01CA220297-05). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10167647. Licensed CC0.

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