# MULTI-OMICS APPROACH ON NIGERIAN MEN WITH PROSTATE CANCER

> **NIH NIH U54** · TUSKEGEE UNIVERSITY · 2020 · $199,302

## Abstract

Project Summary/Abstract
This application is being submitted in response to the Notice of Special Interest (NOSI) identified as
NOT-CA-20-032. Compared to other ancestral groups, men of African ancestry (MAA) have the highest
incidence and mortality of prostate cancer (Prostate cancer), with African men having the highest.
Although socio-economic factors have been shown to contribute to this disparity, the sum of those
factors fails to adequately explain the magnitude of the impact. Multiple studies have demonstrated that
genetic/biologic differences in African American (AA) tumor biology contribute to Prostate cancer
development and aggressiveness. Moreover, there is building evidence to support that the observed
differences are population specific and form unique paths to cancer aggressiveness. Unfortunately,
most contemporary evidence, regarding Prostate cancer in MAA, focus on AA men not African men.
This lack of adequate representation greatly diminishes the ability to not only identify meaningful clinical
interventions for this patient population but also the opportunity to investigate the shared genetic
background of both groups for causal disease variants, overlaid by gene expression. Thus, this
necessitates a greater emphasis on the need for a multi-omics approach to identifying clinical
interventions that can help these underrepresented patient population. To more broadly understand the
role of mutations and that lead to events such as DNA methylation in patients with African Ancestry,
we performed whole exome sequencing of Nigerian Prostate cancer FFPE samples to determine the
mutational landscape of men with prostate cancer in West Africa. Interestingly, we found that a
number of novel mutations, however mutation signatures suggest that Nigerian Prostate tumors contain
a substitution bias toward C>T and T>C transitions, thus increasing the possibilities for DNA
methylation patterns in this population. Furthermore, since our lab for the past decade has
demonstrated that Kaiso is a master regulator of multiple methylated genes expression, and that Kaiso
is associated with suppressive immune microenvironment, we propose the following aims: Specific Aim
1 - Perform DNA methylation profiling on Nigerian Prostate Cancer Patients; and Specific Aim 2
Perform Multi-Spectral Imaging of Nigerian Prostate Cancer FFPE samples.

## Key facts

- **NIH application ID:** 10167916
- **Project number:** 3U54CA118623-15S1
- **Recipient organization:** TUSKEGEE UNIVERSITY
- **Principal Investigator:** Vivian L Carter
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $199,302
- **Award type:** 3
- **Project period:** 2005-09-28 → 2021-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10167916

## Citation

> US National Institutes of Health, RePORTER application 10167916, MULTI-OMICS APPROACH ON NIGERIAN MEN WITH PROSTATE CANCER (3U54CA118623-15S1). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10167916. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*