# Cognitive Control in Children of SUD Parents:  A Longitudinal Multimodal MRI Study

> **NIH NIH R01** · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · 2020 · $159,098

## Abstract

In the context of the COVID-19 pandemic, both economic and racial/ethnic disparities have been dramatically
on display, with life and death consequences. COVID-19 serves as a deadly wake-up call regarding the need
to better understand how existing social, economic and health disparities are compounded in their consequences
on disadvantaged communities in the wake of disaster, in this case, a deadly pandemic. If we are to develop
improved preparations for responding to future epidemics, it is especially important to understand how COVID-
19 is affecting substance use (SU) and mental health (MH) across different racial/ethnic communities. Therefore,
this Stress and COVID-19 (S&C) Study is designed to address such questions by expanding an ongoing study,
which immediately entered the field and is recruiting a random selection of participants from four ongoing,
longitudinal epidemiologic studies examining the impact of different types of trauma and stress in the York City
metropolitan area, epicenter of COVID-19. Taken together, these studies encompass a broad range of SES and
racial/ethnic diversity (49% minority; 51% white), with the participants thoroughly characterized in multiple waves
of data during key stressors, traumas, as well as thorough diagnostic assessments of SU and MH. The first wave
of the proposed S&C Study, which was initiated in mid-March 2020 to capture early indicators, is interviewing,
via telephone, a random selection (n=1,000) of participants drawn from four ongoing studies (N=6,178) including
the Parent Grant study which is focused on a (98%) minority population, and assessing the multifaceted impacts
that COVID is CURRENTLY having, especially on SU and MH behaviors, expecting a sample of N=800.
This Supplement is requested to support the follow-up phase, which will consist of two additional waves of data
collection, at six and nine months after the conclusion of the first wave (months 1-3) and analysis of all waves of
data. This Supplement will allow for a longitudinal trajectory analysis of the COVID-19 impact on SU and MH
outcomes. Importantly, this S&C Study design also allows for the utilization of 2-4 waves of detailed pre-COVID-
19 data on each subject, including SU and MH behaviors and diagnoses, and a wide range of important risk
factors for post-COVID outcomes. Thus, this Supplement will support the investigation of which factors predict
COVID-driven trajectories of SU and MH outcomes, as well as other COVID-driven life changes. The cohorts
being combined for this study were originally chosen for their unique exposures to different forms of childhood
trauma: including disaster (9/11), parental involvement with the criminal justice system and parental SUD., Thus,
this proposed study will help us determine how prior trauma impacts subsequent COVID-19 behaviors, especially
SU and MH across different exposures and across disparate racial/ethnic and socioeconomic groups. Taken
together, the design features of this propo...

## Key facts

- **NIH application ID:** 10168168
- **Project number:** 3R01DA038154-05S3
- **Recipient organization:** NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
- **Principal Investigator:** Christina W. Hoven
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $159,098
- **Award type:** 3
- **Project period:** 2020-05-01 → 2021-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10168168

## Citation

> US National Institutes of Health, RePORTER application 10168168, Cognitive Control in Children of SUD Parents:  A Longitudinal Multimodal MRI Study (3R01DA038154-05S3). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10168168. Licensed CC0.

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