# Data Core

> **NIH NIH U19** · COLD SPRING HARBOR LABORATORY · 2021 · $1,855,686

## Abstract

DATA CORE SUMMARY
The effort to conduct a large-scale and comprehensive cell census within the mammalian brain will depend
upon the systematic and careful handling of massive, multi-dimensional datasets. The proposed center will
focus on generating a whole brain cell transcriptome atlas integrated with a forebrain cell anatomy atlas.
Towards this end, the Data Core will support the other Cores and Research Segments by developing and
implementing a common structural framework that can manage the data's inherent complexity. Specifically, the
Data Core will map, manage, and analyze the single cell-level data generated across the project, including
transcriptomes, dendritic/axonal morphology, and cell body location data. The common reference framework
will be designed to permit web-based access and visualization of the primary data and facilitate efficient data
transfer to the U24-funded data center (BCDC). Data Core lead Dr. Partha Mitra (CSHL) and co-lead, Dr. Aviv
Regev (Broad Institute), will leverage existing frameworks designed to manage, analyze, and distribute high-
resolution anatomical data (the Mouse Brain Architecture program at CSHL) and single cell transcriptome data
(the Single Cell Portal at Broad). Specific activities of the Data Core will include developing statistically
controlled high performance algorithms for biological knowledge discovery, data preprocessing and quality
control, atlas mapping of individual brains onto a reference brain, and development and maintenance of a
single unified data access portal.

## Key facts

- **NIH application ID:** 10168622
- **Project number:** 5U19MH114821-05
- **Recipient organization:** COLD SPRING HARBOR LABORATORY
- **Principal Investigator:** PARTHA Pratim MITRA
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $1,855,686
- **Award type:** 5
- **Project period:** 2017-09-21 → 2023-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10168622

## Citation

> US National Institutes of Health, RePORTER application 10168622, Data Core (5U19MH114821-05). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10168622. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*