# Nonhuman Primate Antibody Resource for Immune Cell Depletion

> **NIH NIH P40** · UNIV OF MASSACHUSETTS MED SCH WORCESTER · 2020 · $323,571

## Abstract

Project Summary
The Nonhuman Primate Reagent Resource (NHPRR) develops recombinant biological materials to support
research with animal models of human diseases. In our parent P40 award, we produce and distribute
approximately 400g of recombinant protein reagents per year. Therefore, we have the tools, expertise, and
infrastructure to manufacture recombinant reagents and distribute them widely. Very recently, coronavirus
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease (COVID) was declared a pandemic,
which prompted the development of new animal models. Unfortunately, the potentially infectious nature of
COVID samples has precluded the exchange of reference serum samples among centers developing monkey
models of COVID. Thus, our plan is to create safe recombinant reference macaque immunoglobulin standards
to facilitate the development and validation of reliable assays for the detection of pathogenic coronaviruses and
antiviral antibodies in NHP animal models of COVID. Specifically, this supplement will fund the generation of the
following reagents: recombinant coronavirus-reactive rhesus monoclonal IgGs (Aim 1) and NHP serum reference
standards (Aim 2). These macaque reference antibody reagents will improve the performance and comparability
of antibody-based assays for NHP models by facilitating serum assay development, proficiency training, and
inter-laboratory performance comparisons at the NPRCs (see letters of support).

## Key facts

- **NIH application ID:** 10168817
- **Project number:** 3P40OD028116-01S1
- **Recipient organization:** UNIV OF MASSACHUSETTS MED SCH WORCESTER
- **Principal Investigator:** Kathleen Engelman
- **Activity code:** P40 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $323,571
- **Award type:** 3
- **Project period:** 2020-01-01 → 2024-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10168817

## Citation

> US National Institutes of Health, RePORTER application 10168817, Nonhuman Primate Antibody Resource for Immune Cell Depletion (3P40OD028116-01S1). Retrieved via AI Analytics 2026-05-28 from https://api.ai-analytics.org/grant/nih/10168817. Licensed CC0.

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