# Clinical Core

> **NIH NIH P01** · WASHINGTON UNIVERSITY · 2021 · $336,001

## Abstract

Core B: Clinical Project Summary/Abstract
Core B: Clinical supports the Adult Children Study (ACS) Program Project Grant (PPG) by recruiting, enrolling
and longitudinally following adult children, age 45-74 years at entry, of parents with and without symptomatic
Alzheimer disease (AD). ACS participants age 45-64y will have clinical and psychometric assessments at
entry and every 3 years thereafter (annually for ACS participants >65y); all participants have imaging and fluid
biomarker procedures at baseline and every 3 years thereafter. The Core is essential in that it supplies
carefully characterized participants to all relevant Cores and Projects. The Clinical Core interacts directly or
indirectly on a daily basis with virtually every facet of the ACS PPG.
The functions of the Core are to:
1. Recruit, enroll, and maintain the ACS cohort at ~300 active participants to support the Projects in this
 application. Twenty-five new participants <65y will be enrolled each year to replenish the younger groups
 due to aging into the ≥65y group.
2. Comprehensively assess the ACS participants with well-established clinical and psychometric instruments
 at entry and every three years (annually for participants >65 years of age). With this application, the clinical
 instruments will be augmented with a questionnaire to assess social determinants of health.
3. Obtain blood from all participants for apolipoprotein E (APOE) genotyping and banking of extracted DNA
 and plasma (supported by the Knight ADRC Genetics and High Throughput –Omics Core with costs
 covered by ACS).
4. Coordinate the participation of ACS participants in the procedures of the Fluid Biomarker Core and all
Projects:
 Project 1 – Tau Burden and Spatial Spread in Preclinical Alzheimer Disease
 Project 2 – Plasma and CSF Biomarkers that Predict Risk for Symptomatic Alzheimer Disease
 Project 3 – Alzheimer Disease Progression, Host Gut Microbiome, and Enteric Dysfunction
 Project 4 – Mechanisms and Moderators of the Effects of Physical Activity in Preclinical Alzheimer Disease
5. Integrate all Core data with the DMBC, and interact cooperatively with all components of the PPG.
6. Encourage the retention of ACS participants by safeguarding their research data, monitoring the
 participants' burden as they complete the protocols of the Cores and Projects, annually sharing with them
 research results, and soliciting their input into the Aims and operations of the ACS.

## Key facts

- **NIH application ID:** 10168840
- **Project number:** 2P01AG026276-16
- **Recipient organization:** WASHINGTON UNIVERSITY
- **Principal Investigator:** JOHN MORRIS
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $336,001
- **Award type:** 2
- **Project period:** 2005-07-01 → 2026-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10168840

## Citation

> US National Institutes of Health, RePORTER application 10168840, Clinical Core (2P01AG026276-16). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10168840. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*