# Bruker scimaX™ Magnetic Resonance Mass Spectrometer

> **NIH NIH S10** · MEDICAL UNIVERSITY OF SOUTH CAROLINA · 2021 · $1,746,141

## Abstract

The Medical University of South Carolina requests funds to purchase a Fourier Transform Ion Cyclotron
Resonance Mass Spectrometer Scimax to support NIH-funded glycomic, lipidomic, and proteomic imaging mass
spectrometry experiments from nine users and two program projects. These investigators form a unique
research nexus focused on understanding disease signatures of glycosylation, sphingolipid signaling and
collagen regulation. The group leverages the fundamental concept that imaging mass spectrometry tools and
equipment can be used to scan any solid surface to rapidly probe molecular expression. This has allowed our
user group to combine array-based imaging of small volumes of biofluids and array-based imaging of small
numbers of cells with tissue imaging to understand mechanisms of N-glycosylation, ceramide signaling and
collagen type turnover and post-translational modification. The group has a strong synergistic research program
of new analytical tool development that is immediately used to answer critical questions on cancer disparities,
prognosis or diagnosis of cancer, immune response, oxidative stress imbalance, metabolic deregulation, protein
misfolding, sphingosine trafficking, reactive stroma, and markers of transplant failure. Importantly, this work is
primarily done on human tissues, so that it is immediately applicable towards understanding human disease
research and can be applied to clinical trials. The current FT-ICR instrument was installed in 2012 and runs at
capacity 24/7. This instrument is aging and has significant downtime for repairs. The new instrument will allow
our investigators to jump forward to state-of-the-art technology with 1) increased acquisition speeds, 2) increased
sensitivity, 3) increased mass resolving power, and 4) multiple fragmentation capabilities that can be directly
coupled to identification strategies for imaging workflows. We have identified the Scimax Magnetic Resonance
Mass Spectrometer as the FT-ICR imaging mass spectrometer that will best suit the needs of our research
group. Our institutional support is strong and our group has combined decades of expertise in biomedical studies
by FT-ICR. Obtaining the Scimax will allow us to continue our highly productive and unique NIH-funded research
on mechanisms of glycomics, lipidomics, and collagen proteomics.

## Key facts

- **NIH application ID:** 10168983
- **Project number:** 1S10OD030212-01
- **Recipient organization:** MEDICAL UNIVERSITY OF SOUTH CAROLINA
- **Principal Investigator:** Peggi M Angel
- **Activity code:** S10 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $1,746,141
- **Award type:** 1
- **Project period:** 2021-09-06 → 2022-09-05

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10168983

## Citation

> US National Institutes of Health, RePORTER application 10168983, Bruker scimaX™ Magnetic Resonance Mass Spectrometer (1S10OD030212-01). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10168983. Licensed CC0.

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