# Core G Neuropath

> **NIH NIH U19** · JOHNS HOPKINS UNIVERSITY · 2021 · $571,271

## Abstract

NEUROPATHOLOGY CORE – CORE G: PROJECT SUMMARY/ABSTRACT
The BIOCARD study is a longitudinal, observational study of 349 individuals who were cognitively normal and
primarily middle aged (mean age=57.1) at enrollment. The subjects have now been followed for up to 27 years.
The overall objectives of the project are to further advance the study of preclinical Alzheimer’s disease
by: (1) clarifying the pattern and rate of change in AD biomarkers (including those based on CSF, blood, MRI,
and PET imaging) and cognition; the biomarkers to be studied include several promising novel biomarkers
derived from blood, CSF and brain imaging. (2) maximizing our data by working collaboratively with several
research groups who have comparable data, and (3) providing a publicly accessible data, brain scans, and
biological specimens, for researchers in the field. To accomplish these goals we established 7 Cores and, with
this application, are also including 2 projects. The Neuropathology Core (Core G) is responsible for
overseeing the neuropathological assessment of brain tissue from participants in the BIOCARD study
and for assuring the integration of these findings with relevant data collected by the other Cores and
Projects. The specific aims include: (1) to maintain a registry of prospective brain donors, (2) to arrange and
perform neuropathologic autopsies, (3) to provide neuropathologic diagnoses, (4) to integrate neuropathology
data with data from other Cores and Projects, (5), to prepare, store and distribute autopsy brain tissue for
research, and (6) to continue investigations of the early pathogenesis of Alzheimer’s disease.

## Key facts

- **NIH application ID:** 10169197
- **Project number:** 5U19AG033655-13
- **Recipient organization:** JOHNS HOPKINS UNIVERSITY
- **Principal Investigator:** JUAN TRONCOSO
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $571,271
- **Award type:** 5
- **Project period:** 2009-07-01 → 2024-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10169197

## Citation

> US National Institutes of Health, RePORTER application 10169197, Core G Neuropath (5U19AG033655-13). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10169197. Licensed CC0.

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