# Core B: Neuropathology Core

> **NIH NIH P01** · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2021 · $157,711

## Abstract

ABSTRACT
Core B is a Neuropathology and Biomarker Core (NP Core) that plays a vital role in the UCSF FTD PPG. FTLD
neuropathology has become increasingly exciting and complex in recent years, with major advances arising
from work accomplished through this PPG. In this renewal application, we propose to continue to cultivate a
world-class FTLD-oriented neurodegenerative disease brain bank at UCSF. The NP Core aims to: (1) Obtain
CNS tissue for NP characterization and banking by performing timely autopsies on patients and healthy
controls ascertained through the Clinical Core; (2) Analyze specimens and document NP diagnoses by
dissecting a standard set of 23 tissue blocks for routine histological staining and systematic
immunohistochemical characterization, resulting in semi-quantitative and quantitative assessments; (3) Enter
NP findings into a comprehensive research-oriented database; (4) Bank CNS tissues, blood, plasma, and CSF,
analyze CSF for putative diagnostic biomarkers, and distribute biospecimens to qualified investigators; (5)
Engage with PPG collaborators in conducting FTLD clinico-pathological research by meeting regularly with
PPG Project leaders who rely on NP Core data; and (6) Train the next generation of neuropathology leaders
and clinical scientists grounded in neuropathology principles and methods by holding consensus and clinico-
pathological conferencesThese core functions will support the aims of Projects 3 (Emotions), 4 (Clinical
criteria), and 7 (Language) by providing final neuropathological diagnoses that serve as primary outcomes or
grouping variables as well as semi-quantitative and/or quantitative regional pathological data. Moreover, the
NP Core will help to further develop a unique bank of specially handled CNS tissues (brain, spinal cord, and
CSF) for ongoing and future FTLD molecular, translational, clinicopathological, and biomarker discovery
research.

## Key facts

- **NIH application ID:** 10169202
- **Project number:** 5P01AG019724-20
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- **Principal Investigator:** WILLIAM W SEELEY
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $157,711
- **Award type:** 5
- **Project period:** 2002-09-01 → 2023-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10169202

## Citation

> US National Institutes of Health, RePORTER application 10169202, Core B: Neuropathology Core (5P01AG019724-20). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10169202. Licensed CC0.

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