# Dissecting the mechanism and function of DNMT3A in neural development

> **NIH NIH F31** · WASHINGTON UNIVERSITY · 2021 · $31,962

## Abstract

DNA methylation is important for proper neuronal development and improper DNA methylation is associated with
numerous neurological disorders such as autism and intellectual disability. The proposed research will utilize
genomic approaches to examine how disease mutations in DNA methyltransferase 3a (DNMT3A) lead to altered
neuronal methylation and investigate how loss of DNMT3A affects neuronal transcription. This work will establish
how DNMT3A functions in healthy and diseased neurons to carefully regulate transcription in a cell-type-specific
manner.

## Key facts

- **NIH application ID:** 10169239
- **Project number:** 5F31HD100098-02
- **Recipient organization:** WASHINGTON UNIVERSITY
- **Principal Investigator:** Diana Christian Beard
- **Activity code:** F31 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $31,962
- **Award type:** 5
- **Project period:** 2020-05-01 → 2022-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10169239

## Citation

> US National Institutes of Health, RePORTER application 10169239, Dissecting the mechanism and function of DNMT3A in neural development (5F31HD100098-02). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10169239. Licensed CC0.

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