# Protocol Review and Monitoring System

> **NIH NIH P30** · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2021 · $329,460

## Abstract

Protocol Review and Monitoring System: Summary/Abstract 
The objectives of the PRMS are to promote optimal review of the scientific merit, priorities and progress of all 
clinical research at the Center. PRMS functions are accomplished by rigorous review in a two-step process 
consisting of disease focused Site Committees, where initial clinical protocol feasibility and prioritization as well 
as assessment of accrual rates is undertaken, and the distinct Protocol Review Committee (PRC). The scope 
of the PRC encompasses review of the scientific rationale, study design, expected accrual rates, adequacy of 
biostatistical input, feasibility for completion within a reasonable time period, prioritization in terms of scientific 
merit and patient availability, and review of scientific progress including reasonable study goals and accrual 
rates. Only trials that receive Site Committee approval are subsequently forwarded to the PRC, which has final 
PRMS authority in adjudicating all protocols, from initial approval all the way through to termination.

## Key facts

- **NIH application ID:** 10169285
- **Project number:** 5P30CA082103-22
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- **Principal Investigator:** Jennifer Leigh Clarke
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $329,460
- **Award type:** 5
- **Project period:** 1999-08-05 → 2023-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10169285

## Citation

> US National Institutes of Health, RePORTER application 10169285, Protocol Review and Monitoring System (5P30CA082103-22). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10169285. Licensed CC0.

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