PROJECT SUMMARY/ABSTRACT The Holden Comprehensive Cancer Center (HCCC) functions administratively as a matrix cancer center, with administrative staff providing support to 170 HCCC members who have over $23.4 million in direct annual cancer-related, peer-reviewed, external research support, including $11.0 million from the NCI. The administrative office of HCCC excels in providing strategic and operational support across the full complement of services that advance the clinical, research and education missions of HCCC. The outstanding growth and development that has occurred during this past funding cycle is a direct reflection of the advanced capabilities of the administrative team to strategically plan, advocate for, grow and refine operations to meet current and future demands.