PROJECT SUMMARY/ABSTRACT The Holden Comprehensive Cancer Center (HCCC) uses developmental funds to advance the research mission of the HCCC based on the HCCC strategic plan and to address the needs of the HCCC catchment area. This includes supporting promising research through seed grants, new faculty recruitments in areas of high priority for HCCC research and support for a staff investigator. Developmental fund support for the P30 is combined with institutional and philanthropic resources to achieve these goals. Two classes of seed grants are awarded to support new cancer research ideas. These grants are named in memory of prior HCCC investigators. Oberley Award recipients are selected by program leaders based on the most promising, high risk research taking place within their programs. In some cases, program leaders have chosen to work across programs to select Oberley Awards to support interprogrammatic collaborations that address issues of high priority for the catchment area. Mezhir Awards are provided to support transdisciplinary team science with a focus on new teams that have promise for larger P-award level funding. Developmental funds are used to support recruitment of both senior and junior faculty. These recruitments focus on areas where there is a particular need as outlined in the HCCC strategic plan, including for scientific leadership within the HCCC. Finally, developmental funds are used to support staff investigators who fill a unique role in the cancer center. In the upcoming funding period, such funding is requested for Maria Spies, PhD who leads the HCCC DNA repair group.