ABSTRACT: The Administrative Core (Admin Core) of the program project “Mechanisms of the BRCA-network in Tumorigenesis and Therapeutic Response” will effectively manage all aspects of the P01 program through an optimally organized administrative team, leveraging expertise in biostatistics and pathology to ensure scientific rigor, fostering an effective communication environment, overseeing proper appreciation of resources, and ensuring relevant polices are properly followed. The Admin Core will accomplish these goals through four specific aims. Aim 1 provides a management structure with a well-qualified core Leader and a Co-leader, an Executive Committee composed of leaders of the research projects and the shared resource cores, an Advisory Committee composed of internal and external members with strong scientific expertise and experience in program management, and a program coordinator. A clear chain of command is built in this management structure. Aim 2 provides strong statistic and pathological expertise to the program investigators. This ensures unified high standards of research rigor. Aim 3 ensures effective communication among the investigators, NIH program officers, institutional administrators, the scientific communities and the general public. Aim 4 will work with institutional financial officers to ensure that the fiscal aspects of the project are soundly managed.