Abstract/Summary The G-RISE program at Oklahoma State University will capitalize on the institution’s long- standing commitment to diversity and the strength of its biomedical research programs to increase the number of PhDs from underrepresented groups who train at OSU and successfully transition into careers in biomedical research. To accomplish this goal, seven program objectives have been developed. 1) Increase the diversity of pre-doctoral trainees in biomedical research at OSU through targeted recruitment activities. 2) Promote rigor, reproducibility and responsible conduct in biomedical research at OSU through a combination of workshops, classroom instruction, and interactive activities. 3) Expose trainees to cutting-edge biomedical science through seminars, programming, and workshops focused on research. 4) Enhance trainees’ oral and written communication skills by providing them with the training and opportunities to present their research in different formats to both scientific communities and the general public. 5) Educate students about the range of career opportunities available for PhDs in the biomedical scientists. 6) Retain talented biomedical sciences doctoral students within the G-RISE program and ensure that their time-to-degree is not increased. 7) Ensure that trainees are ready to transition from pre-doctoral training to the next step in their scientific career by the completion of their program. OSU G-RISE will support 6 new trainees each year for up to 3 years, beginning the second year of their doctoral training. With 33 outstanding faculty mentors from across 12 participating doctoral programs, students will have the opportunity to train in a wide variety of fields, including physiology, pharmacology, comparative biomedical sciences, medicinal chemistry, microbiology, immunology, virology, cell/molecular biology, biochemistry, biomedical engineering, neuroscience, psychology and parasitology. The OSU G-RISE program is well-grounded in strong institutional support and is ideally positioned to provide new opportunities for exceptional students from underrepresented groups, as well as disadvantaged and disabled students, to train for successful careers in biomedical research.