# Administrative Core

> **NIH NIH U19** · HARVARD MEDICAL SCHOOL · 2022 · $167,091

## Abstract

PROJECT SUMMARY – Administrative Core
This Combating Antibiotic Resistant Bacteria (CARB) proposal outlines the design and function of a
multidisciplinary, collaborative partnership applying new and innovative approaches to understand the
mechanisms underlying bacterial envelope assembly and enable the discovery of treatments against multidrug-
resistant infections. Because this is an academic effort, emphasis will be on developing the scientific knowledge
that will allow discovery of new compounds and protein therapeutics for especially challenging and unexploited
targets involved in cell envelope biogenesis, with membrane proteins and protein complexes a focal point in all
three projects. The project team comprises an accomplished group of scientists with extensive and synergistic
expertise in biochemistry, including reconstitutions of multi-enzyme pathways and large protein machines, in
structural biology of membrane proteins and membrane protein complexes, in approaches for discovery of
components essential for cell envelope biogenesis, in the creative use of genetic screens to dissect the
regulation of pathways important in cell division and envelope biogenesis, and in development of new
technologies and screening approaches for discovery of antimicrobial compounds and therapeutic proteins.
Synergistic expertise in both the Gram-negative and Gram-positive cell envelopes is also well-represented
among the project team members. The scientific expertise of the project team will be complemented by
substantial administrative experience. The goal of the CARB Administrative Core therefore is to oversee the
smooth implementation of the research plan and deployment of resources, and to foster the cohesive and well-
functioning whole to achieve goals that are greater than the sum of the individual projects. This will be
accomplished by achieving the following Specific Aims: 1) Provide program management, oversight, and
compliance assurance, 2) Facilitate regular interactions among CARB investigators and trainees from the various
labs and projects in a smooth and effective manner, and promote connectivity with other Harvard-wide initiatives;
3) Provide critical infrastructure for fiscal management of the program; 4) Provide a single point of contact and
active coordination for on-going communication with NIAID, the Program Officer, and other NIAID staff and
initiatives. The Administrative Core will foster the continued development of a highly functioning, well integrated,
and synergistic whole to contribute to much-needed scientific advances in a challenging area of research that
holds considerable promise for overcoming antibiotic resistance, while generating resources and fostering data
sharing with the greater scientific community.

## Key facts

- **NIH application ID:** 10169872
- **Project number:** 1U19AI158028-01
- **Recipient organization:** HARVARD MEDICAL SCHOOL
- **Principal Investigator:** Suzanne Walker
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2022
- **Award amount:** $167,091
- **Award type:** 1
- **Project period:** 2022-09-07 → 2026-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10169872

## Citation

> US National Institutes of Health, RePORTER application 10169872, Administrative Core (1U19AI158028-01). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10169872. Licensed CC0.

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