Component: DISSEMINATION PROJECT SUMMARY/ABSTRACT Dissemination and training are at the core of Xenbase’s mission to accelerate the translation of research using Xenopus into knowledge that will impact human health. Our goals are to enable research using Xenopus, make high-quality curated data available to Xenopus researchers, facilitate the dissemination of Xenopus data to the broader biomedical community, and to help improve data literacy in the Xenopus community. We follow the FAIR data management principles which aim to make data Findable, Accessible, Interoperable and Reusable. We curate data, link data from Xenopus to humans and model organisms and provide curated datasets to external resources including: NCBI, UCSC, GO Consortium, UniProt, Ensembl and other model organism knowledgebases (MOKs). We plan to establish new exchanges with a number of resources such as the Monarch Initiative, the Alliance of Genomic Resources (AGR), DIOPT and the European Bioinformatics Institute. All our code, bio-informatic pipelines and processed data reports are freely available. Xenbase also provides critical data-sharing infrastructure for many other NIH- funded projects, most notably the Xenopus genomes. Xenbase has also become a focal point for the Xenopus community and we provide outreach, education, and training activities. In sum, Xenbase has become the single most important clearing house of data from Xenopus research and the communication hub for the Xenopus community. Aim 1. Continue open access dissemination of Xenbase content using the FAIR principles. Aim 2. Enhance dissemination by improving the user interfaces and data-sharing infrastructure. Aim 3. Community Communication, Outreach, and Training.