Administrative Core Summary/Abstract The overall goal of the Administrative Core is to maximize integration of all projects and cores, and collaborations among Program Investigators and Core leaders. This Core is essential for coordinating the scientific, financial, organizational, and monitoring activities, and facilitating inter-project interactions of this multi-project grant to maximize the success of the overall multi-project research program. The Core will be led by Dr. Elizabeth Jaffee, who has extensive experience overseeing scientific programs at the Sidney Kimmel Cancer Center at Johns Hopkins, as well as a number of multi-project NIH funded programs. Dr. Jaffee recently served as the Team Leader for a multi-site, multiple principal investigator grant through Stand Up To Cancer. Dr. Daniel Laheru will serve as co-leader of this Core. Dr. Laheru brings many years of experience conducting clinical trials in pancreatic cancer and serves as the co- director of the Gastrointestinal Cancer program and co-director of the Skip Viragh Pancreatic Cancer Center for Clinical Research and Clinical Care. The specific aims are to: 1) Provide organizational and administrative management to insure success of all projects and cores within the program; and 2) Facilitate scientific collaborations and program oversight through the coordination of scientific and advisory board meetings for the investigators in this program. Drs. Jaffee and Laheru will monitor progress of all Projects and Cores, identify challenges or hurdles, and assist with problem solving. The Administrative Assistant to Drs. Jaffee and Laheru, will be responsible for oversight of the distribution and usage of funding provided to the individual programs and Cores. She will also provide monthly financial reports for all projects and cores within the program, assist investigators with non-competitive renewal applications, and provide support for manuscript preparation and submission. Drs. Jaffee and Laheru will convene weekly scientific meetings for all members of the Program Project, and monthly meetings of Project and Core Leaders to ensure adequate communication between and integration of all Project and Core teams. There will also be quarterly meetings with the internal advisory board to monitor and provide input on the group’s scientific progress. In addition, there will be an annual one-day scientific retreat to include all investigators and the internal and external scientific advisors. A closed advisory board meeting will be held at the conclusion of the retreat for the advisors to provide objective feedback to the program investigators.