# Protective role of dectin-1 signaling in an animal model of Multiple Sclerosis

> **NIH NIH F30** · DUKE UNIVERSITY · 2021 · $44,577

## Abstract

ABSTRACT
Multiple sclerosis (MS) is an autoimmune disorder of the central nervous system (CNS) affecting an estimated
2.5 million people worldwide. Recent work strongly implicates the innate immune system in the development of
both MS and its animal model, Experimental Autoimmune Encephalomyelitis (EAE). C-type Lectin Receptors
(CLR) are a major class of pattern recognition receptors (PRR) that can initiate innate immune responses, but
their role in autoimmune disease and in MS is largely unknown. My preliminary data demonstrates that the
CLR dectin-1 has an unexpected protective role in EAE. Mice lacking dectin-1 develop more severe EAE, and
a single injection of a dectin-1 agonist can reduce disease incidence and severity. The primary objective of this
project is to dissect the mechanisms by which dectin-1 signaling is protective in CNS autoimmune disease,
using EAE as a model. Recently, I found that dectin-1 signaling can upregulate the neuroprotective factor,
Oncostatin M (Osm) in myeloid cells. Based on my preliminary data, this upregulation appears to occur through
a non-canonical dectin-1 signaling pathway independent of CARD9 and RAF1. Additionally, I found that a
recently identified endogenous ligand for dectin-1 is upregulated in EAE and can similarly induce Osm. In this
proposal, I will determine the cell subsets and ligands responsible for protective dectin-1 signaling and I will
uncover the mechanism and function of dectin-1 induced Osm in EAE. By identifying and dissecting protective
innate immune signaling by dectin-1 in EAE, this research has the potential to reveal novel targets for
immunotherapy in MS.

## Key facts

- **NIH application ID:** 10170219
- **Project number:** 5F30AI140497-04
- **Recipient organization:** DUKE UNIVERSITY
- **Principal Investigator:** Marion Elizabeth Deerhake
- **Activity code:** F30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $44,577
- **Award type:** 5
- **Project period:** 2018-08-01 → 2022-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10170219

## Citation

> US National Institutes of Health, RePORTER application 10170219, Protective role of dectin-1 signaling in an animal model of Multiple Sclerosis (5F30AI140497-04). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10170219. Licensed CC0.

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