# Genomic Acquisition and Analysis (GAA)

> **NIH NIH P20** · UNIVERSITY OF NEVADA LAS VEGAS · 2021 · $288,917

## Abstract

ABSTRACT: GASP CORE 
 Genetic studies have provided clear evidence that virtually all human traits studied in biomedical research, 
including disease susceptibility, treatment responses, relapses and side effects, are influenced by genetic 
makeup. It is, therefore, essential to incorporate genetic information in medical research and practice to 
achieve optimal outcome. As genetic information is encoded in genomic DNA, to understand the genetic 
architecture of a disease or trait, or to dissect the genetic makeup of an individual, we have to conduct DNA 
sequencing of the genome of that individual. In this personalized medicine focused COBRE application, we 
intend to integrate and disseminate genetic and genomic data, and apply them to personalize health issues 
proposed by individual projects. The genome analysis and sequencing pipeline (GASP) core is designed to 
support individual projects by providing services for DNA/RNA sequencing, data integration, dissemination and 
analyses. Since bioinformatics and biostatistics have become a critical component in genomic and genetic 
studies, the core will also provide expertise and services to support each project to accomplish its goals. The 
specific aims of the core are: 
 1. To conduct genomic experiments to acquire data required by each individual project. These 
 experiments could be the sequencing of exome/whole genome, or enriched portion of genome 
 (methylation or targeted genes/pathways), genotyping of specified genetic variants or profiling of gene 
expression. 
 2. To provide bioinformatics support for individual projects. This service includes data quality control, the 
 establishment of analytic and annotation pipelines and the generation of analysis-ready data sets for 
 downstream analyses. 
 3. To provide genetic analysis service to individual projects. These services include the identification, 
 annotation and characterization of genetic variants, evaluation of genetic risks, and genetic association 
analyses. 
 4. To assist and coordinate other omics services required by individual projects. Project 3 will analyze 
 blood samples for protein components and metabolites. We do not have sufficient resource in this 
 COBRE to conduct these proteomics and metabolomics analyses. Other projects and pilot studies may 
 need other omics services as well. Therefore, we propose to coordinate with the project leaders and 
 help them to find appropriate vendors for these services.

## Key facts

- **NIH application ID:** 10170372
- **Project number:** 5P20GM121325-04
- **Recipient organization:** UNIVERSITY OF NEVADA LAS VEGAS
- **Principal Investigator:** XIANGNING CHEN
- **Activity code:** P20 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $288,917
- **Award type:** 5
- **Project period:** 2020-06-01 → 2023-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10170372

## Citation

> US National Institutes of Health, RePORTER application 10170372, Genomic Acquisition and Analysis (GAA) (5P20GM121325-04). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10170372. Licensed CC0.

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