# Molecular Neurogenetics of Olfactory Driven Aggression and Social Hierarchy in a Model Insect System

> **NIH NIH R01** · VANDERBILT UNIVERSITY · 2021 · $313,904

## Abstract

Project Summary
Humans and many other animals exhibit a wide variety of social behaviors. Traditionally, primates have been
used as research models of human behavior due to their close evolutionary relationship to humans and their
highly social behavior. However, the use of primates for such research has significant economic, practical, and
ethical drawbacks, and, in that light, it would be useful to find other models for behavioral studies that exhibit
complex social behaviors. One potential model that fits both criteria is the extensive family of insects
collectively known as the ants, some species of which exhibit highly complex “eusocial” behaviors involving a
strict division of labor between sterile workers and reproductive queens. Among ant workers, there is a further
division of labor, with different tasks allocated among different castes of workers.
Our hypothesis is that caste/colony-specific aggression and social hierarchy reflect and in-part are determined
by chemosensory programs dictated largely through odorant receptors and shifts in neuropeptidomic profiles.
We will investigate this question in two ant species—Camponotus floridanus and Harpegnathos saltator—that
exist in large colonies that are composed of just a few males, and the remainder are females, including one
(typically) queen, and numerous workers that engage in caste/colony specific aggressive behaviors such as
defense, policing and dueling.

## Key facts

- **NIH application ID:** 10170383
- **Project number:** 5R01GM128336-04
- **Recipient organization:** VANDERBILT UNIVERSITY
- **Principal Investigator:** LAURENCE J ZWIEBEL
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $313,904
- **Award type:** 5
- **Project period:** 2018-08-16 → 2024-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10170383

## Citation

> US National Institutes of Health, RePORTER application 10170383, Molecular Neurogenetics of Olfactory Driven Aggression and Social Hierarchy in a Model Insect System (5R01GM128336-04). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10170383. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*