# Mechanism of Fibroblast Growth Factor 2-Mediated Alveolar Epithelial Repair

> **NIH NIH K08** · UNIVERSITY OF CHICAGO · 2021 · $163,944

## Abstract

PROJECT SUMMARY
 This proposal describes a five-year research and training plan that will facilitate the transition of Dr. Robert
Guzy, MD, PhD to an independent academic researcher. Dr. Guzy is a cell and molecular biologist and adult
pulmonologist at the University of Chicago, and is building a career as a physician scientist with an interest in
lung injury and pulmonary fibrosis. He has a strong background in basic science research and medicine and
has completed post-graduate training in Internal Medicine and Pulmonary/Critical Care Medicine. The primary
training goal of this K08 proposal is to provide the framework and support necessary for Dr. Guzy to 1) extend
his experience with murine models of lung injury, 2) build a fund of knowledge in macrophage biology, 3)
develop expertise in translational studies, 4) develop expertise in transcriptomics, and 5) transition to
independent scientific investigation in pulmonary disease.
 This work will be carried out at The University of Chicago under the supervision of Dr. Gokhan Mutlu, MD.
The University of Chicago is renowned for its strength in many research disciplines, including translational
pulmonary medicine. Dr. Mutlu is an international leader in lung injury research and macrophage biology, and
has a highly successful track record of mentoring. An advisory committee with diverse expertise will provide
career guidance and scientific feedback. A detailed career development plan is proposed that includes a
timeline for development of new skills, preparation of manuscripts for publication, and an eventual R01
application in a pathway to independence.
 The proposed research plan will focus on mechanistic studies of FGF2 signaling in lung injury. Preliminary
studies performed by Dr. Guzy demonstrate that FGF2 is expressed in macrophages in response to lung injury
in mice and humans. Furthermore, mice lacking FGF2 (Fgf2-/-) have increased mortality and deficient alveolar
epithelial recovery in response to bleomycin. This study proposes a model in which macrophage-derived
FGF2 is required for recovery from lung injury by directly promoting proliferation of lung epithelium
and subsequent differentiation into mature alveolar epithelial cells. This will be approached with three
Specific Aims: Aim 1: Determine the requirement of macrophage-derived FGF2 expression in response to lung
injury. Aim 2: Determine the requirement of FGFRs in Type 2 AECs for recovery after lung injury. Aim 3:
Determine the capacity for FGF2 to provide an enhanced reparative signal after lung injury.
 In total, these studies will be critical for developing a mechanism of FGF2/FGFR-mediated epithelial
recovery after lung injury, and will be the basis for future applications of FGF2 to promote recovery in patients
with ARDS. Additionally, results of this project will serve as a foundation for future NIH R01 applications and a
career as an independent pulmonary physician scientist.

## Key facts

- **NIH application ID:** 10170402
- **Project number:** 5K08HL125910-05
- **Recipient organization:** UNIVERSITY OF CHICAGO
- **Principal Investigator:** Robert David Guzy
- **Activity code:** K08 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $163,944
- **Award type:** 5
- **Project period:** 2017-06-05 → 2022-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10170402

## Citation

> US National Institutes of Health, RePORTER application 10170402, Mechanism of Fibroblast Growth Factor 2-Mediated Alveolar Epithelial Repair (5K08HL125910-05). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10170402. Licensed CC0.

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