# FDA LFFM: Discipline-Special Projects  Analytical Track-Method Development and Method Validation at CT AES

> **NIH FDA U19** · CONNECTICUT AGRICULTURAL EXPERIMENT STA · 2020 · $35,000

## Abstract

PROJECT SUMMARY- METHOD DEVELOPMENT AND VALIDATION 
SPECIAL PROJECT 
FDA LFFM: Discipline-Special Projects; Method Development and Validation at CT AES 
Project Summary- This proposal is being submitted in response to RFA-PAR-20-105 Laboratory 
Flexible Funding Model (LFFM)(U19). The Connecticut Agricultural Experiment Station (CT 
AES) has a 145-year history of food safety research, including 15 years as a member of the FDA 
Food Emergency Response Network (FERN) Chemistry Cooperative Agreement Program 
(cCAP), and 8 years of funding under 4 different FDA ISO food safety CAPs. For this Method 
Development and Validation Project, the goal is conduct preliminary, short-term or exploratory 
investigations that focus on the feasibility of a new method and/or technology. We propose 9 
projects that include activities such as proof of concept for new analytical approaches, method 
development for representative food matrices, single laboratory validations of methods, matrix or 
platform extensions or multi-laboratory validation research studies. Some of these projects could 
become multi-year projects, dependent on results and FDA approval. We also recognize that 
project opportunities may change annually, as requested by FDA. These projects are: 1) Single 
laboratory validation of LC-MS/MS methods for pesticides in new matrices. 2) Multi-laboratory 
validation of Elemental Analysis Manual method EAM 4.12: analysis of bottled water by ICP- 
MS. 3) Protein analysis by LC-HRMS and LC-MS/MS. 4) Portable Hand-Held X-Ray 
Fluorescence Determination of Toxic Elements EAM 4.9. 5) Multi-laboratory validation of 
method for Arsenic speciation in seafood using LC-ICP-MS. 6) Detection of PFASs in animal feed 
using LC-HRMS/MS. 7) Multi-laboratory validation LC/MS/MS method for vet drug residues in 
raw milk, milk, and powdered milk. 8) Non-targeted analysis of unknown toxins in food using LC- 
HRMS/MS, Compound Discoverer, and Hydrophilic Interaction Chromatography (HILIC). 9) 
Single laboratory validation of mycotoxins in hemp and hemp-derived products. 
 The CT AES has demonstrated the expertise, capability, and adaptability to fully meet the 
objectives of this RFA through our successful participation in a number of FDA CAPs. Receipt of 
this new award from FDA will significantly enhance the ability of the CT AES specifically, and 
CT in general, to meet the program goals laid out in the RFA, and as described by the President’s 
Food Safety Working Group, the Partnership for Food Protection and the Food Safety 
Modernization Act. 
1

## Key facts

- **NIH application ID:** 10170743
- **Project number:** 1U19FD007094-01
- **Recipient organization:** CONNECTICUT AGRICULTURAL EXPERIMENT STA
- **Principal Investigator:** JASON C WHITE
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** FDA
- **Fiscal year:** 2020
- **Award amount:** $35,000
- **Award type:** 1
- **Project period:** 2020-09-01 → 2025-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10170743

## Citation

> US National Institutes of Health, RePORTER application 10170743, FDA LFFM: Discipline-Special Projects  Analytical Track-Method Development and Method Validation at CT AES (1U19FD007094-01). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10170743. Licensed CC0.

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