# Core C: Sample Biorepository and Analytics Core

> **NIH NIH U19** · BRIGHAM AND WOMEN'S HOSPITAL · 2020 · $199,053

## Abstract

The Sample Biorepository and Analytics Core Facility (Core C) will continue to provide a secure, standardized,
and readily accessible source of human and mouse biologic samples that are integral to testing the hypotheses
proposed in the three Projects of this AADCRC. Sample information will be maintained in an FDA-compliant
digital database that will be accessible by investigators in Core B to identify samples available for molecular
informatics analyses. Core C will also provide standardized and cost-effective methodology for extraction of
RNA, protein, and lipid mediators, and for histologic processing and analysis of tissue samples. In addition, the
Core will provide state of the art liquid chromatography-tandem mass spectrometry analyses with high
sensitivity and the ability to identify >20 eicosanoids from a single sample, which will be essential for
quantifying specific mediators as well as defining eicosanoid profiles in patient-derived samples in Projects 1
and 3, as well as the mouse studies in Project 2. The Core activities were implemented during the current
funding period, with start-up costs being supported by an Administrative Supplement. Thus, all of the
necessary organization, personnel, software, and equipment are already in place. Because this Core supports
all three Projects as well as Core B, it is central to the integration of the AADCRC as a whole.

## Key facts

- **NIH application ID:** 10171014
- **Project number:** 5U19AI095219-10
- **Recipient organization:** BRIGHAM AND WOMEN'S HOSPITAL
- **Principal Investigator:** HOWARD R KATZ
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $199,053
- **Award type:** 5
- **Project period:** — → 2021-07-22

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10171014

## Citation

> US National Institutes of Health, RePORTER application 10171014, Core C: Sample Biorepository and Analytics Core (5U19AI095219-10). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10171014. Licensed CC0.

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