# SIREN - CORE-EM HUB ALLIANCE

> **NIH NIH U24** · EMORY UNIVERSITY · 2021 · $127,249

## Abstract

The CORE-EM Alliance (COalition for REsearch in Emergency Medicine) brings to SIREN six highly
experienced research infrastructures, each with their own 5 spokes, partnering to create an innovative single
super hub in the 10-hub SIREN network. The goal of CORE-EM is to provide a highly functioning infrastructure
for rapid implementation and high quality performance of large pragmatic clinical trials for a wide variety of
emergency conditions including, neurology, cardiovascular, respiratory, hematologic, and trauma related
emergencies. Our model is remarkably flexible and efficient, as we can be as lean as six independent sites, or
have the ability to rapidly expand to 30-plus enrolling sites. The CORE-EM leverages veteran leadership and
experienced research teams with a long history of prior successful collaboration and exemplary clinical trial
performance and provides SIREN access to an impressively diverse patient population, spanning large
geographic regions within the Southern and Eastern United States. The CORE-EM Alliance will easily be
capable of implementing four or more simultaneous large (>1,000 patient), simple, pragmatic trials in the
Emergency Department (ED) and out of hospital settings. CORE-EM is committed to being an extraordinary
partner for SIREN with a focus on conducting rigorous trials and assessments of novel therapeutic
interventions in an aim to improve the lives of our patients.

## Key facts

- **NIH application ID:** 10171627
- **Project number:** 5U24NS100673-05
- **Recipient organization:** EMORY UNIVERSITY
- **Principal Investigator:** Elizabeth B. Jones
- **Activity code:** U24 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $127,249
- **Award type:** 5
- **Project period:** 2017-07-15 → 2023-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10171627

## Citation

> US National Institutes of Health, RePORTER application 10171627, SIREN - CORE-EM HUB ALLIANCE (5U24NS100673-05). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10171627. Licensed CC0.

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