# Histology

> **NIH NIH P30** · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · 2021 · $255,329

## Abstract

Histology Core: Project Summary/Abstract
Koch Institute Members use vertebrate model organisms as a key tool to study the role of known or putative
cancer genes in development and tumorigenicity; investigate the mechanisms of tumor initiation, progression
and metastasis; evaluate the role of stroma and immune responses in tumorigenesis; and assess the efficacy
of drugs, nanomaterials and devices in therapeutic and diagnostic applications. Thus, it is essential that Center
Members are able to correctly diagnose developmental and tumor phenotypes, evaluate the underlying
molecular events, and accurately and quantitatively assess drug or vaccine delivery, localized tissue response,
and overall therapeutic response. The Koch Institute Histology Core is a Shared Resource that provides state-
of-the-art histological services to support these studies. This includes assistance and/or training in tissue
sectioning, slide preparation, staining and analysis, and access to the consultative services of an
internationally recognized Veterinary Pathologist, Dr. Roderick Bronson, for diagnosis of tumor and tissue
phenotypes.
During the current period, usage of the Histology Core increased from 67% to 77% of Center Members, and
included investigators from all three Programs. In response to Center member needs, the Histology Core
expanded services and instrumentation. This includes expanded offerings for immunohistochemistry and
special stains, and investigator training for independent sectioning. The Core also acquired new digital slide
scanning capabilities and quantification software, and made upgrades to existing key instrumentation. Thus,
this Shared Resource is essential to the success of the Koch Institute mission.
In the upcoming period, The Histology Core is committed to offering a wide range of state-of-the-art histological
services to support the research programs of Center Members. Planned initiatives include: working with the
Integrated Genomics & Bioinformatics Core to establish methodologies for mapping gene expression at the
single cell level within tissues; developing expertise and providing guidance in use of automated AI-driven
analysis packages (such as QuPath) for analysis of histological sections; evaluating instrumentation to
determine community benefit for fluorescent digital slide scanning; and expanding histology training offerings to
include more hands-on workshop opportunities. This shared Core is of exceptional value to the CCSG because
Koch Institute Members account for 95% of the Core services usage. Notably, the requested CCSG budget for
Year 49 is 6.8% less than the budget in the current period (Year 48).

## Key facts

- **NIH application ID:** 10171799
- **Project number:** 5P30CA014051-50
- **Recipient organization:** MASSACHUSETTS INSTITUTE OF TECHNOLOGY
- **Principal Investigator:** Omer Yilmaz
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $255,329
- **Award type:** 5
- **Project period:** 1997-06-17 → 2025-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10171799

## Citation

> US National Institutes of Health, RePORTER application 10171799, Histology (5P30CA014051-50). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10171799. Licensed CC0.

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