# Respiratory Computational Discovery Core

> **NIH NIH P01** · WEILL MEDICAL COLL OF CORNELL UNIV · 2021 · $379,824

## Abstract

Abstract
 The goal of the Respiratory Computational Discovery Core (Core B) is to provide a collaborative infrastructure
in which experienced statisticians and computational and systems biologists will work together to support the
various PPG Projects to develop testable hypotheses about genomic features associated with COPD and IPF,
and the functional roles of these genes in disease pathogenesis. In this capacity, the Core will serve a dual role.
The Core’s analytical team will work closely with the members of the PPG Projects and Cores to design
experiments and analyze the resulting data using “conventional” methods, with an emphasis on elucidating the
functions of key genes implicated in pulmonary disease. These analyses will be augmented by the development
and application of advanced analytical methods aimed at integrating diverse types of data into an interpretable
biological framework, providing testable hypotheses regarding drivers of disease progression. The rationale
behind creating a separate Core is to supplement the strong quantitative analytical teams working on each of
the various Projects with bioinformatics and systems-based modeling expertise and to standardize and integrate
data across Projects. In addition, we will develop methods to allow us to more effectively compare results
between human and mouse model studies, facilitating the translation of laboratory results into biological and
clinical insight that will advance our understanding of the role that key genes, including those involved in
mitochondrial and chitinase processes, play in disease development and differentiate COPD and IPF.

## Key facts

- **NIH application ID:** 10172309
- **Project number:** 2P01HL114501-06A1
- **Recipient organization:** WEILL MEDICAL COLL OF CORNELL UNIV
- **Principal Investigator:** John Quackenbush
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $379,824
- **Award type:** 2
- **Project period:** 2013-09-06 → 2026-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10172309

## Citation

> US National Institutes of Health, RePORTER application 10172309, Respiratory Computational Discovery Core (2P01HL114501-06A1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10172309. Licensed CC0.

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