This institutional research training program provides opportunities for promising PhD students and post- doctoral fellows to train for careers in biomedical research related to Diabetes, Obesity, and Metabolic Complications. During its first four years (2015-present), this training grant provided support four ten trainees – including five pre-doctoral trainees (two of whom received their PhD degrees) and five post-doctoral fellows one of whom is supported by a Diversity Administrative supplement. The central features of the Program include intensive research in the laboratory of the participating faculty member and didactic training in basic science, translational research, and clinical investigation. Research areas span a wide range of scientific disciplines – including physiology, biochemistry, pharmacology, neurosciences, genetics, toxicology, and molecular medicine. The faculty mentors are highly productive researchers who serve as Principal Investigators on peer reviewed research grants from the National Institutes of Health as well as private foundations such as the American Diabetes Association and the Juvenile Diabetes Research Foundation. Pre- doctoral trainees are recruited from the Graduate Program in Life Sciences (GPILS) at the University of Maryland Baltimore. Post-doctoral trainees are recruited from leading research laboratories – primarily within the United States. The mentors’ research teams employ a wide variety of scientific methods including modern biochemical and molecular studies of hormone action. Expertise in biochemistry, cell biology, molecular biology, human genetics, neurobiology, toxicology, and physiology are all well represented by the faculty. Primary facilities are located in the University of Maryland School of Medicine – the oldest public medical school in the United States. During its first four years of existence, faculty from the following academic Departments have mentored trainees: Medicine, Physiology, Anatomy & Neuroscience, and Obstetrics & Gynecology. This Program has been funded to support two PhD students and two post-doctoral trainees.