# Analytic

> **NIH NIH P01** · UNIVERSITY OF ARIZONA · 2021 · $444,438

## Abstract

PROJECT SUMMARY – ANALYTIC CORE
The mission of the Perimenopause in Brain Aging and Alzheimer’s Disease (P3) is to discover biological
transformations in brain that occur during the perimenopausal transition that lead to endophenotypes predictive
of risk for Alzheimer’s disease (AD). Each year ~1.5 million American women enter into the perimenopause, a
neuroendocrine transition state unique to the female. Herein, we focus on the neuro-immune system as a key
driver of chronological and endocrinological aging that occurs in the midlife female brain. Our goals are to identify
the mechanisms by which these transformations occur and to translate these discoveries into strategies to
prevent conversion to an at-Alzheimer's-risk phenotype. Analytic Core contributes to meeting P3 goals by
providing standardized sample banking, tracking, processing and distribution, as well as analytic and
bioinformatic support across the Program Project. To achieve this mission, the Analytic Core will provide three
levels of support. The first level of support entails standardized sample processing, quality control and sample
management. The second level of support entails sample analysis on four major studies: tissue bulk RNA-
sequencing gene expression analysis, single-cell / single-nucleus RNA-sequencing, global metabolomic analysis
and comprehensive lipidomic analysis. The last level of support entails -omics data processing, bioinformatic
analysis and interpretation. Outcomes of Analytic Core support will enable achieving the Perimenopause in Brain
Aging and Alzheimer’s Disease Program Project mission and aims through the infrastructure and analytic and
informatic capabilities it has developed. The P3 program of research addresses key strategic goals of the
National Institutes on Aging’s 2016: Aging Well in the 21st Century: Strategic Directions for Research on Aging,
specifically Goals A (1,2,3,7,8,11) & D (1,2,4).

## Key facts

- **NIH application ID:** 10172747
- **Project number:** 2P01AG026572-16
- **Recipient organization:** UNIVERSITY OF ARIZONA
- **Principal Investigator:** Fei Yin
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $444,438
- **Award type:** 2
- **Project period:** 2006-08-15 → 2026-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10172747

## Citation

> US National Institutes of Health, RePORTER application 10172747, Analytic (2P01AG026572-16). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10172747. Licensed CC0.

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