# Maternal and Cord Blood Metabolome, Infant Feeding, and Development of Food Allergy in a Prospective Birth Cohort

> **NIH NIH R21** · JOHNS HOPKINS UNIVERSITY · 2021 · $204,688

## Abstract

ABSTRACT
The rising prevalence of food allergies (FA) in the past decades is in parallel with growing obesity and diabetes
epidemics, first in developed countries and now across the world. It raises the question whether maternal
metabolic disorders are etiologically related to the rising prevalence of FA in children? Research findings from
us and others have lent support that maternal metabolic disorders may increase the risk of child FA. However,
the underlying molecular mechanisms are not well studied. Besides, it is well-observed that risk of developing
FA varies greatly across individual children, even after controlling for maternal metabolic conditions. This
raises another question: To what degree can early life environment and/or genetic factors modify the
associations between maternal metabolic conditions and child development of FA? This proposal, highly
motivated by our intriguing previous work and promising preliminary data, aims to systematically investigate
the longitudinal relationships of maternal and cord blood metabolome (a comprehensive characterization of
maternal and fetal circulating metabolites) with child development of FA in the Boston Birth Cohort (BBC). We
will leverage the BBC’s extensive clinical and epidemiological databases, FA phenotypes, along with existing
maternal and cord metabolomic and genome-wide genotype data from 1,500 mother-infant pairs (including 300
children with FA). We propose to address the following three novel specific aims: Aim 1. To examine
prospective associations of maternal and cord blood metabolome with child development of FA. We
hypothesize that unfavorable maternal and cord blood metabolome profiles can independently and jointly
increase child FA risk. We will further explore whether the identified FA-associated metabolites can explain or
modify the impact of maternal metabolic disorders on child FA risk. Aim 2. To examine the role of infant
feeding pattern in the relationships between maternal and cord metabolome and child development of FA. We
hypothesize that infant feeding pattern (including breastfeeding and duration, and the timing and type of solid
food introduction) may modify the associations observed in Aim 1. Aim 3. To explore the role of fetal genome
in the associations observed in Aims 1 and 2. Finally, we seek to integrate multi-dimensional data
(epidemiological, clinical, metabolomic and genomic data) to better characterize newborns’ future risk for
development of FA. This would be the first large-scale prospective birth cohort study to integrate cutting-edge
metabolomics to address critical questions about early-life metabolic origins of FA under a life course frame.
As such, our proposal is well-poised to gaining new insight on early metabolic risk of FA and to identify novel
metabolite biomarkers in the pathways from maternal metabolic disorders to child development of FA. Such
information will improve our ability to identify newborns at high risk of developing FA and impl...

## Key facts

- **NIH application ID:** 10172845
- **Project number:** 5R21AI154233-02
- **Recipient organization:** JOHNS HOPKINS UNIVERSITY
- **Principal Investigator:** Xiumei Hong
- **Activity code:** R21 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $204,688
- **Award type:** 5
- **Project period:** 2020-07-01 → 2023-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10172845

## Citation

> US National Institutes of Health, RePORTER application 10172845, Maternal and Cord Blood Metabolome, Infant Feeding, and Development of Food Allergy in a Prospective Birth Cohort (5R21AI154233-02). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10172845. Licensed CC0.

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