# The Ohio Valley Node of the Clinical Trials Network

> **NIH NIH UG1** · UNIVERSITY OF CINCINNATI · 2021 · $1,198,077

## Abstract

Project Summary (Abstract):
Since its establishment in 2000, the Ohio Valley Node (OVN) has been one of the most productive of NIDA's
Clinical Trials Network (CTN) nodes, both in leading and participating in multi-site trials. The OVN includes
successful partnerships with four healthcare systems, two pharmacy networks, and six addiction specialty/
infectious disease programs. These collaborating sites span a seven-state region including some of the states
most heavily impacted by opioid (Ohio, Kentucky, and West Virginia) and methamphetamine (Missouri,
Kentucky, and North Dakota) use. The OVN includes Midwestern, Appalachian, Upper South, and Native
American representation, which significantly enhances the geographical and cultural diversity of the CTN. The
OVN Research Core is the driving force of the OVN and is led by Dr. Winhusen, one of the foremost experts in
conducting multi-site addiction clinical trials in clinical practice settings. The OVN investigators have extensive
expertise in substance use disorders (Winhusen, Brown, Burlew, Lyons, Montgomery, Lofwall, Walsh) and
bioinformatics (Kaelber, Xu). The six members of the OVN research-implementation team bring > 60 years of
combined experience conducting CTN clinical trials. If funded, our overall goal would be to utilize the wealth of
experience and expertise gained over the past 19 years to conduct the research needed to address public
health care crises, including the opioid use epidemic and the alarming increase in stimulant use. To this end,
we would work with our healthcare partners to engage a diverse set of patients and service systems in areas
highly impacted by substance use in CTN research. We would also contribute our expertise in conducting
efficacy, effectiveness, and implementation trials testing the full range of interventions, from medications to
behavioral interventions and health service innovations, for both opioid and stimulant use disorders. Moreover,
we would contribute our expertise in the use of electronic health records for prospective and retrospective
research studies, including the application of artificial intelligence to large healthcare datasets. In sum, we seek
to continue providing scientific leadership, particularly on studies that could meaningfully impact clinical
practice, and to effectively collaborate with a variety of professionals including treatment providers,
investigators from diverse institutions, and staff of the Center for CTN (CCTN), clinical coordinating center
(CCC) and data and statistics center (DSC) in support of the CTN mission.

## Key facts

- **NIH application ID:** 10172880
- **Project number:** 5UG1DA013732-22
- **Recipient organization:** UNIVERSITY OF CINCINNATI
- **Principal Investigator:** T John WINHUSEN
- **Activity code:** UG1 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $1,198,077
- **Award type:** 5
- **Project period:** 2000-09-30 → 2025-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10172880

## Citation

> US National Institutes of Health, RePORTER application 10172880, The Ohio Valley Node of the Clinical Trials Network (5UG1DA013732-22). Retrieved via AI Analytics 2026-05-21 from https://api.ai-analytics.org/grant/nih/10172880. Licensed CC0.

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