# Support for Infrastructure of Childhood Leukemia Environmental Research

> **NIH NIH R24** · UNIVERSITY OF CALIFORNIA BERKELEY · 2021 · $366,856

## Abstract

ABSTRACT
Leukemia is the most common pediatric cancer affecting more than 40,000 children worldwide each year. During
the last three decades, childhood leukemia (CL) incidence has increased in the US by ~35% overall, with an
even larger rise among Latinos. This rapid increase implicates environmental factors in CL etiology, possibly in
combination with genetic factors. Despite improved treatments for many types of CL, survivors remain at risk for
serious complications. The role of environmental factors play in the development of long-term CL complications
is unknown. The overarching objective of this proposal is to maintain, enhance, and enrich the infrastructure of
two existing NIEHS-funded environmental case-control studies of CL conducted in ethnically-diverse populations
of California (California Childhood Leukemia Study; CCLS, 1995-2016) and Guatemala (CRECERÉ study; 2013-
2015). The CCLS has collected a wealth of environmental and genetic data, and assembled a rich inventory of
biospecimens and dust samples for up to 2213 CL cases and 1310 controls, making it the most comprehensive
CL study worldwide. The CCLS has produced seminal findings, documenting the prenatal origin of CL and
identifying many factors that contribute to the development of the disease including: chemical exposures, diet,
immune response, and genetic factors. CCLS also supported the development of novel laboratory methods for
genome-, epigenome-, and exposome-wide studies of archived newborn dried blood specimens. The
maintenance of CCLS resources and the enhancement of data sharing procedures are needed to efficiently
expand ongoing etiologic and tumor-biology studies of CL and also to begin new studies on emerging research
areas such as prevention, early detection, intervention, and survivorship. Our group has also completed a pilot
study of CL in Guatemala that enrolled 50 cases and 50 controls in collaboration with established hospital
networks, and collected biospecimens as well as genetic and environmental data with a focus on indoor air
pollution. Maintaining these resources is critical to support future expansion of the study in this vulnerable
population. In addition, the CCLS--45% of which is comprised of Latino children--and the Guatemala study will
support future projects dedicated to identifying the causes of the ethnic disparity in CL risk. These studies will
also continue to participate in the Childhood Leukemia International Consortium, as one of the select member
cohorts from around the world that include children of Latin American descent. To achieve our goal, we plan to
1) curate and manage the inventory of existing biospecimens (e.g., bone marrow, blood, DBS, saliva, urine),
dust samples, and data from medical records, interviews, geographic information system, and laboratory assays;
(2) upgrade the biorepository and database capabilities, and (3) enhance data sharing by improving the relational
databases used for timely data queries and project plann...

## Key facts

- **NIH application ID:** 10172904
- **Project number:** 5R24ES028524-05
- **Recipient organization:** UNIVERSITY OF CALIFORNIA BERKELEY
- **Principal Investigator:** Catherine Metayer
- **Activity code:** R24 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $366,856
- **Award type:** 5
- **Project period:** 2017-09-30 → 2022-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10172904

## Citation

> US National Institutes of Health, RePORTER application 10172904, Support for Infrastructure of Childhood Leukemia Environmental Research (5R24ES028524-05). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10172904. Licensed CC0.

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