# Equipment Supplement Requisition for Mesoscale Quick Plex SQ 120mm Reader

> **NIH NIH R01** · EAST TENNESSEE STATE UNIVERSITY · 2020 · $59,900

## Abstract

This administrative supplement request to purchase equipment is being submitted in response to PA-18-591
(NIGMS Program of Administrative Supplements for Equipment). My currently funded R01 GM122934 is
the parent award for this supplemental request. I am requesting funding for a Mesoscale QuickPlex SQ
120. The critically ill patient frequently develops a complex disease spectrum that may include systemic
inflammatory response syndrome, sepsis syndrome, septic shock and/or multiple organ dysfunction
syndrome. In the United States ~951,000 patients/year develop sepsis with approximately half of these
patients in the ICU. The overall mortality rate is 28.6%. Those patients that survive the initial septic event
may ultimately succumb to widespread organ dysfunction due to ongoing immune dysfunction. It is well
accepted that sepsis causes suppression of the immune system, and that sepsis-induced immunoparalysis
predisposes the critically ill patient to secondary infections. Secondary fungal infections are one of the most
serious, as they are difficult to diagnose and treat. Attempts at developing effective therapies to prevent or
treat sepsis and its associated immunosuppression have proven to be exceedingly difficult. In fact, no drugs
are currently approved by the FDA for the management of sepsis. A very important aspect of this research
is to establish the impact of sepsis on leukocytes and innate immune parameters in sepsis. To achieve this
goal, we will critically analyze cytokines, chemokines and biomarkers from sepsis patients. This will require
a detection sensitivity and dynamic range that is far beyond our current capabilities. The Mesoscale
QuickPlex SQ 120 that is requested in this supplement will fill this critical and unmet need. In addition, the
increase capabilities of the SQ 120 will allow us to more critically evaluate our working hypotheses.

## Key facts

- **NIH application ID:** 10173094
- **Project number:** 3R01GM122934-04S1
- **Recipient organization:** EAST TENNESSEE STATE UNIVERSITY
- **Principal Investigator:** Tammy Regena Ozment
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $59,900
- **Award type:** 3
- **Project period:** 2017-08-15 → 2022-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10173094

## Citation

> US National Institutes of Health, RePORTER application 10173094, Equipment Supplement Requisition for Mesoscale Quick Plex SQ 120mm Reader (3R01GM122934-04S1). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10173094. Licensed CC0.

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