# Indiana Alzheimer Disease Center

> **NIH NIH P30** · INDIANA UNIVERSITY INDIANAPOLIS · 2020 · $368,906

## Abstract

Project Summary – IADC Overall
The Indiana Alzheimer Disease Center (IADC) was established in 1991 to bring investigators and institutional
resources at the Indiana University School of Medicine together to address the fundamental causes and
treatment of Alzheimer's disease (AD) and other dementias. Despite many important gains, the need for
targeted research is greater than ever, with an estimated 5.3 million people in the U.S. suffering from AD and
related dementias. Unfortunately, we do not yet know how to prevent AD or have an approved disease
modifying intervention. Both are critical to stem the growth in dementia prevalence. The overarching goal of the
IADC going forward is to support the U.S. National Plan for AD (National Alzheimer's Project Act, NAPA) to
prevent and effectively treat AD by 2025 through innovative research on etiology, early detection, and
therapeutics. Biomarker studies indicate that processes leading to AD begin at least 20 years prior to
dementia, and increasing evidence suggests that successful interventions will have to be implemented early.
This presents a great potential opportunity for early intervention, but the field is challenged by critical barriers
decreasing the prospects of timely success. The IADC has identified the barriers as: a) gaps in understanding
the basic biology of AD leading to over-simplified approaches; b) the need for sensitive, specific, and cost-
effective methods for early detection of those at risk or with emerging symptoms; c) the identification of novel
therapeutic targets including non-pharmacological lifestyle modification approaches, as well as interventions
for caregivers and social support strategies for patients; d) a compelling need to train the next generation of
translational researchers who can bridge basic science and clinical trials; and e) the need for new models of
care delivery and greater inclusiveness of underrepresented groups. The IADC has four major goals directed
toward overcoming these barriers and accelerating the pace of research toward prevention and effective
treatment: (1) Support, enhance, and expand innovative research on AD and related dementias targeting
causes, diagnosis, treatment, and prevention; (2) Provide critical research resources and infrastructure to
support existing studies and enable new innovative research, including pilot studies. Key resources include a
well-characterized longitudinal clinical cohort and access to promising new methods including advanced
imaging (multimodal MRI, amyloid and tau PET), genetics, biomarkers, and advanced bioinformatics and
systems biology. Together these resources will facilitate a better understanding of disease mechanisms, novel
discovery, and translation to the clinical healthcare environment; (3) Strongly support local, regional, and
national/international dementia research collaborations; and, (4) Provide educational and training opportunities
related to dementia for learners of all levels and needs includi...

## Key facts

- **NIH application ID:** 10173119
- **Project number:** 3P30AG010133-30S1
- **Recipient organization:** INDIANA UNIVERSITY INDIANAPOLIS
- **Principal Investigator:** ANDREW J SAYKIN
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $368,906
- **Award type:** 3
- **Project period:** 1997-07-15 → 2022-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10173119

## Citation

> US National Institutes of Health, RePORTER application 10173119, Indiana Alzheimer Disease Center (3P30AG010133-30S1). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10173119. Licensed CC0.

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