# Method Development/Validation Multi-laboratory validation of method for Arsenic speciation in seafood using LC-ICP-MS (Discipline D: Special Projects Analytical Track 3)

> **NIH FDA U19** · WADSWORTH CENTER · 2020 · $32,862

## Abstract

PROJECT SUMMARY 
The overall goal of this special project is to conduct a preliminary, exploratory investigation of the feasibility of 
developing a new method for arsenic (As) speciation in seafood based on a simple extraction procedure with 
separation and detection using LC-ICP-MS. The proposed project will leverage the current expertise and 
capabilities at the Wadsworth Center, where a simple LC-ICP-MS method has already been developed, and 
which could be validated for use across the FERN network by multiple laboratories. Specific objectives will 
include exploring the feasibility of combining As(III) and As(V) by oxidizing the former to the latter, to produce a 
single inorganic As species (iAs). Other objectives will include deciding how many different As species should 
be captured in the proposed method, while recognizing calibration standards exist only for limited number of As 
species. A key objective will be to produce a suitable candidate reference material based on a seafood 
product matrix that can be homogenized, and distributed to multiple laboratories for the first interlaboratory 
study. Other objectives will include a single laboratory validation of the proposed method, and the design of the 
first interlaboratory round robin to gather baseline data on network capabilities

## Key facts

- **NIH application ID:** 10173141
- **Project number:** 1U19FD007089-01
- **Recipient organization:** WADSWORTH CENTER
- **Principal Investigator:** Patrick J. Parsons
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** FDA
- **Fiscal year:** 2020
- **Award amount:** $32,862
- **Award type:** 1
- **Project period:** 2020-09-01 → 2025-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10173141

## Citation

> US National Institutes of Health, RePORTER application 10173141, Method Development/Validation Multi-laboratory validation of method for Arsenic speciation in seafood using LC-ICP-MS (Discipline D: Special Projects Analytical Track 3) (1U19FD007089-01). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10173141. Licensed CC0.

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