# Microbiology - Whole Genome Sequencing Analytical Track

> **NIH FDA U19** · OHIO STATE DEPARTMENT OF AGRICULTURE · 2020 · $106,650

## Abstract

Increasing the Capability and Capacity of 
Microbiological and Chemical Testing to Support an 
Integrated Food Defense and Food Safety System 
Microbiology Discipline, Whole Genome Sequencing Analytical Track 
Project Summary / Abstract 
This Project proposal is part of a Multi Project Application from the Ohio Department of 
Agriculture (ODA) in response to Funding Opportunity Announcement (FOA) # PAR-20-105 
from the Food and Drug Administration’s (FDA) Office of Regulatory Affairs (ORA), Center for 
Veterinary Medicine (CVM) and Center for Food Safety and Applied Nutrition (CFSAN). This 
proposal from ODA’s Animal Disease Diagnostic Laboratory (ADDL) addresses the key project 
areas as described in Microbiology Analytical Track 4 (Whole Genome Sequencing (WGS)) of 
the FOA. The ADDL is prepared to achieve the ‘High’ Sample Load of at least 400 isolates 
sequenced in 1 year. The ADDL utilizes the Illumina MiSeq and iSeq platforms, ensuring the lab 
has the ability to sequence human or animal food, and environmental isolates for Listeria 
monocytogenes, Salmonella and Shiga toxin-producing E. coli (STEC). Importantly, in 2019 the 
ADDL achieved ISO 17025 accreditation of its WGS method for gram-negative and gram- 
positive bacteria isolates. We are confident that we can meet the objectives of this project and 
look forward to the opportunity to work with the FDA.

## Key facts

- **NIH application ID:** 10173193
- **Project number:** 1U19FD007087-01
- **Recipient organization:** OHIO STATE DEPARTMENT OF AGRICULTURE
- **Principal Investigator:** YAN ZHANG
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** FDA
- **Fiscal year:** 2020
- **Award amount:** $106,650
- **Award type:** 1
- **Project period:** 2020-09-01 → 2025-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10173193

## Citation

> US National Institutes of Health, RePORTER application 10173193, Microbiology - Whole Genome Sequencing Analytical Track (1U19FD007087-01). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10173193. Licensed CC0.

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