# Discovering new genes involved in protective T-cell responses through the generation of mice with targeted mutations

> **NIH NIH R21** · THOMAS JEFFERSON UNIVERSITY · 2021 · $195,000

## Abstract

Abstract
 T-cells play major functions to combat infectious diseases and cancer, are critical for the
effectiveness of vaccines, and may have negative effects in various types of immune disorders.
While many of the genes involved in T-cell responses have been identified, it is likely that many
remain unknown. The discovery of these genes and their specific roles during in vivo immune
responses could provide major advances in our understanding of the immune system and for
the improvement of vaccines and/or treatment of infectious diseases, cancer, and various
immune disorders. Here we propose to generate mice with T-cell deletions of genes whose
transcription is perturbed in specific T-cell populations during protective anti-viral T-cell
responses. Our hypothesis is that some of these genes will play essential roles in immune
responses to pathogens and possible in cancer and various immune dysfunctions. The mouse
models developed through this grant will provide new valuable information about the role of still
little-known genes in the modulation of the anti-viral immune response and resistance to viral
infection and may be the basis of future novel discoveries encompassing not only immunology
but other areas of mammalian biology.

## Key facts

- **NIH application ID:** 10173635
- **Project number:** 5R21AI153920-02
- **Recipient organization:** THOMAS JEFFERSON UNIVERSITY
- **Principal Investigator:** Luis J Sigal
- **Activity code:** R21 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $195,000
- **Award type:** 5
- **Project period:** 2020-06-01 → 2023-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10173635

## Citation

> US National Institutes of Health, RePORTER application 10173635, Discovering new genes involved in protective T-cell responses through the generation of mice with targeted mutations (5R21AI153920-02). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10173635. Licensed CC0.

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