# Integrated Structural Biology Core

> **NIH NIH P30** · UNIVERSITY OF MONTANA · 2021 · $465,574

## Abstract

The Integrated Structural Biology Core (ISBC) facility of the Center for Biomolecular Structure and Dynamics
(CBSD) provides technology and expertise to assist University of Montana (UM) faculty to elucidate biological
processes using the analytical methods of mechanistic and structural biochemistry. Services provided by the
Core include a full suite of gene-to-structure technologies: protein expression and purification, structure
determination by X-ray crystallography and cryo-Electron Microscopy (cryo-EM). The ISBC has the capacity to
conduct a variety of biophysical and analytical measurements of protein thermodynamic and ligand-binding
properties such as surface plasmon resonance and multi-angle light scattering, and supports NMR facilities at
UM for structural analysis of macromolecular structure and dynamics, and structural validation of small organic
molecules. The ISBC has also become a facility for small molecule X-ray crystallography for Montana and the
surrounding Rocky Mountain region, which include three IDeA States. During Phase III of COBRE support the
ISBC seeks: 1) to remain at the methodological forefront of structural biology by, among other activities,
developing capacity for cryo-EM services in collaboration with partners at Montana State University; 2) to
maintain strong and ongoing interactions with other core facilities within CBSD and other COBRE Core
facilities at UM to provide a suite of complementary experimental and analytical tools to solve complex
problems in molecular and cell biology; 3) optimize ISBC reporting processes to effectively track services
provided to clients, evaluate scientific outcomes and impact, and monitor its financial status. The ISBC will
employ evaluation/survey tools to ensure client satisfaction, identify emerging needs and define clear and
transparent mechanisms to prioritize projects. The ISBC will continue to pursue its training mission to
disseminate technologies to client laboratories. Lastly, the ISBC will implement policies to insure its
sustainability beyond Phase III by maintaining a robust fee-for-service program, leveraging institutional support
and pursuing grant-funded collaborations with UM investigators and external users.

## Key facts

- **NIH application ID:** 10174403
- **Project number:** 1P30GM140963-01
- **Recipient organization:** UNIVERSITY OF MONTANA
- **Principal Investigator:** Stephen R Sprang
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $465,574
- **Award type:** 1
- **Project period:** 2021-08-10 → 2026-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10174403

## Citation

> US National Institutes of Health, RePORTER application 10174403, Integrated Structural Biology Core (1P30GM140963-01). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10174403. Licensed CC0.

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