# Resource Support Core - Clinical

> **NIH NIH U54** · MAYO CLINIC ROCHESTER · 2021 · $131,406

## Abstract

RESOURCE SUPPORT CORE – CLINICAL CORE: SUMMARY/ABSTRACT Ekta Kapoor, M.B.B.S.
The Clinical Core will provide management and oversight of the human studies of the SCORE (Project 1 and
2). It will also maintain a shared database for Projects 1 and 2. It will be located in the Clinical Research and
Trials Unit (CRTU) of the Center for Clinical and Translational Science (CCaTS) at Mayo Clinic, Rochester,
and will be comprised of a menopause specialist, a CRTU staff nurse, and a study coordinator. The specific
aims of the Clinical Core are:
Aim 1: To recruit, screen, consent, and enroll study participants for Projects 1 and 2.
Aim 2: To coordinate and complete clinical testing for Projects 1 and 2.
Aim 3: To manage the database for Projects 1 and 2.
We will utilize the Mayo Clinic Cohort Study of Oophorectomy and Aging-2 (MOA-2), an established and well-
characterized population-based cohort study of women with and without premenopausal bilateral salpingo-
oophorectomy (BSO), who are now only passively followed through the Rochester Epidemiology Project (REP)
medical records-linkage system. We will recruit 250 women with, and 250 without premenopausal BSO for an
in-person examination a median of 22 years after their surgery or index date. For Project 1, we will extensively
characterize their physical and cognitive function, and collect blood to measure senescence associated
secretory phenotype (SASP) proteins, a novel marker of aging. In addition, 200 women enrolled in Project 1
(100 with premenopausal BSO and 100 referent) will be invited to participate in Project 2 for neuroimaging
studies of Alzheimer's disease pathology and cerebrovascular disease.
The Clinical Core will contribute to the overall success of the SCORE by providing clinical, nursing,
coordination, and data management expertise.

## Key facts

- **NIH application ID:** 10174626
- **Project number:** 5U54AG044170-09
- **Recipient organization:** MAYO CLINIC ROCHESTER
- **Principal Investigator:** Ekta Kapoor
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $131,406
- **Award type:** 5
- **Project period:** 2012-09-01 → 2023-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10174626

## Citation

> US National Institutes of Health, RePORTER application 10174626, Resource Support Core - Clinical (5U54AG044170-09). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10174626. Licensed CC0.

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