# Modeling HIV Rebound: Role of SIVmac251 Functional Reservoirs and Biomarkers of Reactivation

> **NIH NIH P01** · JOHNS HOPKINS UNIVERSITY · 2021 · $1,631,072

## Abstract

Abstract
Despite fully suppressive ART for long periods of time, HIV rebounds in the majority of
individuals when ART is interrupted. Studies in this proposal will define and quantitate
the functional SIV latent reservoirs in tissue to understand the contributions of both
CD4+T cells and macrophages to the functional viral reservoir and viral rebound after
ART interruption. The SIVmac251 ART suppressed model will be used to quantitate the
functional viral reservoir in CD4+ T cells and macrophages to asses their contribution to
viral rebound. Depletion of CD4 cells and reduction of the latent reservoir will be done to
address whether CD4 cells are the major HIV reservoir or if latently infected
macrophages significantly contribute to HIV rebound. The projects in this Program will
1) Identify the differential contribution of resting CD4+ T cells and resident macrophages
to viral rebound after antiretroviral treatment interruption; 2) Identify the source of viral
rebound using SIV proviral genome analysis; and 3) Use computational modeling and
analyses of SIV virus rebound to understand HIV rebound.

## Key facts

- **NIH application ID:** 10174704
- **Project number:** 5P01AI131306-05
- **Recipient organization:** JOHNS HOPKINS UNIVERSITY
- **Principal Investigator:** JANICE E CLEMENTS
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $1,631,072
- **Award type:** 5
- **Project period:** 2017-06-23 → 2024-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10174704

## Citation

> US National Institutes of Health, RePORTER application 10174704, Modeling HIV Rebound: Role of SIVmac251 Functional Reservoirs and Biomarkers of Reactivation (5P01AI131306-05). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10174704. Licensed CC0.

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